S-adenosylmethionine synthase isoform type-2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P31153. Use UniProt P31153 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P31153 as the stable identity anchor, then attach disease evidence before program review.
S-adenosylmethionine synthase isoform type-2
Review this target as S-adenosylmethionine synthase isoform type-2, mapped to UniProt P31153. Sequence length is 395 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats S-adenosylmethionine synthase isoform type-2 as ChEMBL target CHEMBL3313835, mapped to UniProt P31153. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether S-adenosylmethionine synthase isoform type-2 is the right protein anchor across sources, using UniProt P31153 as the stable mapping.
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| Preferred Name | S-adenosylmethionine synthase isoform type-2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P31153 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | S-adenosylmethionine synthase isoform type-2 |
| UniProt Accession | P31153 |
| Component Type | Protein |
| Sequence Length | 395 aa |
S-adenosylmethionine synthase isoform type-2
Review this target as S-adenosylmethionine synthase isoform type-2, mapped to UniProt P31153. Sequence length is 395 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4573938 | 9.4 | IC50 | 0.3981 | Preclinical |
| CHEMBL5561157 | 9.3 | IC50 | 0.5012 | Preclinical |
| CHEMBL5560496 | 9.1 | IC50 | 0.7943 | Preclinical |
| CHEMBL5555241 | 8.9 | IC50 | 1.259 | Preclinical |
| CHEMBL5566482 | 8.8 | IC50 | 1.585 | Preclinical |
| CHEMBL5558104 | 8.5 | IC50 | 3.162 | Preclinical |
| CHEMBL5562188 | 8.5 | IC50 | 3.162 | Preclinical |
| CHEMBL4521249 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4552959 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL5558255 | 8.4 | IC50 | 3.981 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 26 | 208 | 6.9 |
| single protein format | 24 | 170 | 6.4 |
| assay format | 5 | 22 | 5.4 |
| subcellular format | 1 | 0 | — |