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Target Snapshot

CHEMBL3314 Target Snapshot

Chymotrypsinogen A · SINGLE PROTEIN · Bos taurus

676Compounds
231Assays
1Approved Drugs
407.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P00766. Use UniProt P00766 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P00766 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Chymotrypsinogen A as ChEMBL target CHEMBL3314, mapped to UniProt P00766. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Chymotrypsinogen A
SINGLE PROTEIN · Bos taurus
As of 2026-09-13
ChEMBL target ID
CHEMBL3314
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P00766
Chymotrypsinogen A
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Chymotrypsinogen A is the right protein anchor across sources, using UniProt P00766 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelChymotrypsinogen A
UniProt AccessionP00766
Component TypeProtein
Sequence Length245 aa

Chymotrypsinogen A

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Chymotrypsinogen A, mapped to UniProt P00766. Sequence length is 245 aa.

Mapped IDP00766
Review nameChymotrypsinogen A
OrganismBos taurus
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50223.0
KI182.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL285285 10.96 Ki 0.011 Preclinical
CHEMBL418050 10.68 Ki 0.021 Preclinical
CHEMBL291026 9.94 Ki 0.115 Preclinical
CHEMBL290577 9.82 Ki 0.152 Preclinical
CHEMBL2448441 9.07 Ki 0.848 Preclinical
CHEMBL3349045 8.92 Ki 1.21 Preclinical
CHEMBL287918 8.92 Ki 1.2 Preclinical
CHEMBL288176 8.84 Ki 1.46 Preclinical
CHEMBL291261 8.54 Ki 2.89 Preclinical
CHEMBL36744 8.53 Ki 2.96 Preclinical
Distribution

pChEMBL Value Distribution

36
5.0
41
5.5
24
6.0
30
6.5
19
7.0
3
7.5
1
8.0
5
8.5
1
9.0
2
9.5
pChEMBL
Assay Landscape

Assay Landscape

231
Total Assays
265
Tested Compounds
3
Assay Types
Binding — 222 assays, 265 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 218 262 5.7
tissue-based format 3 3
cell-free format 1 0
Functional — 7 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 7 0
ADME — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine