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Target Snapshot

CHEMBL3317334 Target Snapshot

Proteasome subunit beta type-10 · SINGLE PROTEIN · Homo sapiens

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174Compounds
38Assays
1Approved Drugs
184.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P40306. Use UniProt P40306 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P40306 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Proteasome subunit beta type-10 as ChEMBL target CHEMBL3317334, mapped to UniProt P40306. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Proteasome subunit beta type-10
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3317334
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P40306
Proteasome subunit beta type-10
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Proteasome subunit beta type-10 is the right protein anchor across sources, using UniProt P40306 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameProteasome subunit beta type-10
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP40306
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProteasome subunit beta type-10
UniProt AccessionP40306
Component TypeProtein
Sequence Length273 aa

Proteasome subunit beta type-10

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Proteasome subunit beta type-10, mapped to UniProt P40306. Sequence length is 273 aa.

Mapped IDP40306
Review nameProteasome subunit beta type-10
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Approved
1
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

IC50184.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4297468 9.88 IC50 0.131 Clinical
CHEMBL270515 8.0 IC50 10.0 Clinical
CHEMBL451887 7.89 IC50 13.0 Approved
CHEMBL2326533 7.7 IC50 20.0 Preclinical
CHEMBL4543211 7.66 IC50 22.0 Preclinical
CHEMBL4549724 7.64 IC50 23.0 Preclinical
CHEMBL4471150 7.41 IC50 39.0 Preclinical
CHEMBL4515041 7.35 IC50 45.0 Preclinical
CHEMBL4457630 7.33 IC50 47.0 Preclinical
CHEMBL4550571 7.33 IC50 47.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
13
5.5
29
6.0
23
6.5
10
7.0
5
7.5
1
8.0
0
8.5
0
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

CARFILZOMIB
CHEMBL451887
Approved 2009
Properties Compare Identifier
Assay Landscape

Assay Landscape

38
Total Assays
105
Tested Compounds
2
Assay Types
Binding — 36 assays, 105 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 19 39 5.8
subcellular format 9 16 6.2
cell-based format 6 47 6.3
assay format 2 3 6.6
ADME — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 2 1 4.3

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine