Polymerase basic protein 2 · SINGLE PROTEIN · Influenza A virus (strain A/Puerto Rico/8/1934 H1N1)
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As of 2026-09-14Polymerase basic protein 2 shows clinical signal disease relevance led by influenza. 2 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P03428. Start with influenza, then reuse UniProt P03428 as the stable protein anchor across project notes and exports.
Start with influenza, then reuse UniProt P03428 as the stable protein anchor across project notes and exports.
Polymerase basic protein 2 shows clinical signal disease relevance led by influenza. 2 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with influenza because it currently carries clinical signal support. Linked drugs include PIMODIVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyPolymerase basic protein 2
Review this target as Polymerase basic protein 2, mapped to UniProt P03428. Sequence length is 759 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Polymerase basic protein 2 as ChEMBL target CHEMBL3317339, mapped to UniProt P03428. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Polymerase basic protein 2 is the right protein anchor across sources, using UniProt P03428 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why influenza is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Polymerase basic protein 2 |
| Target Type | SINGLE PROTEIN |
| Organism | Influenza A virus (strain A/Puerto Rico/8/1934 H1N1) |
| UniProt | P03428 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Polymerase basic protein 2 |
| UniProt Accession | P03428 |
| Component Type | Protein |
| Sequence Length | 759 aa |
Polymerase basic protein 2
Review this target as Polymerase basic protein 2, mapped to UniProt P03428. Sequence length is 759 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Polymerase basic protein 2 shows clinical signal disease relevance led by influenza. 2 more disease programs remain visible in the same review block.
Start review with influenza because it currently carries clinical signal support. Linked drugs include PIMODIVIR. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4593027 | 10.22 | EC50 | 0.06 | Preclinical |
| CHEMBL4472219 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL4568323 | 9.7 | EC50 | 0.2 | Preclinical |
| CHEMBL4570851 | 9.4 | EC50 | 0.4 | Preclinical |
| CHEMBL4434862 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL4466462 | 9.3 | EC50 | 0.5 | Preclinical |
| CHEMBL3318007 | 9.22 | EC50 | 0.6 | Clinical |
| CHEMBL4547565 | 8.85 | EC50 | 1.4 | Preclinical |
| CHEMBL4469158 | 8.59 | EC50 | 2.6 | Preclinical |
| CHEMBL4470294 | 8.55 | EC50 | 2.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 33 | 6.8 |
| cell-based format | 4 | 38 | 7.9 |
| assay format | 1 | 7 | 6.2 |