Monoglyceride lipase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q8R431. Use UniProt Q8R431 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q8R431 as the stable identity anchor, then attach disease evidence before program review.
Monoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt Q8R431. Sequence length is 303 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Monoglyceride lipase as ChEMBL target CHEMBL3321, mapped to UniProt Q8R431. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Monoglyceride lipase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q8R431 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Monoglyceride lipase |
| UniProt Accession | Q8R431 |
| Component Type | Protein |
| Sequence Length | 303 aa |
Monoglyceride lipase
Review this target as Monoglyceride lipase, mapped to UniProt Q8R431. Sequence length is 303 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3787346 | 10.11 | IC50 | 0.078 | Preclinical |
| CHEMBL6067709 | 9.92 | IC50 | 0.12 | Preclinical |
| CHEMBL3785379 | 9.8 | IC50 | 0.159 | Preclinical |
| CHEMBL3087181 | 9.67 | IC50 | 0.214 | Preclinical |
| CHEMBL5569248 | 9.66 | IC50 | 0.22 | Preclinical |
| CHEMBL4216513 | 9.57 | IC50 | 0.269 | Preclinical |
| CHEMBL3356956 | 9.23 | IC50 | 0.589 | Preclinical |
| CHEMBL3658400 | 9.01 | IC50 | 0.97 | Preclinical |
| CHEMBL1232635 | 8.96 | IC50 | 1.1 | Preclinical |
| CHEMBL5591381 | 8.92 | IC50 | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 22 | 21 | 4.8 |
| assay format | 20 | 38 | 5.5 |
| cell membrane format | 15 | 35 | 4.7 |
| cell-based format | 12 | 43 | 6.9 |
| single protein format | 11 | 40 | 7.2 |
| microsome format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell membrane format | 1 | 1 | 4.5 |
| organism-based format | 1 | 0 | — |
| tissue-based format | 1 | 1 | 9.0 |