Prostacyclin receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P43253. Use UniProt P43253 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P43253 as the stable identity anchor, then attach disease evidence before program review.
Prostacyclin receptor
Review this target as Prostacyclin receptor, mapped to UniProt P43253. Sequence length is 416 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Prostacyclin receptor as ChEMBL target CHEMBL3322, mapped to UniProt P43253. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Prostacyclin receptor is the right protein anchor across sources, using UniProt P43253 as the stable mapping.
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| Preferred Name | Prostacyclin receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P43253 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Prostacyclin receptor |
| UniProt Accession | P43253 |
| Component Type | Protein |
| Sequence Length | 416 aa |
Prostacyclin receptor
Review this target as Prostacyclin receptor, mapped to UniProt P43253. Sequence length is 416 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL494 | 9.16 | EC50 | 0.69 | Approved |
| CHEMBL494 | 9.0 | Ki | 1.0 | Approved |
| CHEMBL3398233 | 7.96 | EC50 | 11.0 | Preclinical |
| CHEMBL3398215 | 7.9 | EC50 | 12.5 | Preclinical |
| CHEMBL3398220 | 7.55 | EC50 | 28.0 | Preclinical |
| CHEMBL3398229 | 7.4 | EC50 | 40.0 | Preclinical |
| CHEMBL3398219 | 7.29 | EC50 | 51.0 | Preclinical |
| CHEMBL3933704 | 7.29 | Ki | 51.0 | Preclinical |
| CHEMBL3301604 | 7.12 | Ki | 76.0 | Clinical |
| CHEMBL3398228 | 6.96 | EC50 | 110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 4 | 48 | 6.5 |
| assay format | 1 | 2 | 6.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 3 | 7.8 |
| single protein format | 1 | 0 | — |