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Target Snapshot

CHEMBL3332 Target Snapshot

Disintegrin and metalloproteinase domain-containing protein 17 · SINGLE PROTEIN · Sus scrofa

391Compounds
28Assays
0Approved Drugs
434.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt O77636. Use UniProt O77636 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt O77636 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Disintegrin and metalloproteinase domain-containing protein 17 as ChEMBL target CHEMBL3332, mapped to UniProt O77636. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Disintegrin and metalloproteinase domain-containing protein 17
SINGLE PROTEIN · Sus scrofa
As of 2026-09-14
ChEMBL target ID
CHEMBL3332
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
O77636
Disintegrin and metalloproteinase domain-containing protein 17
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Disintegrin and metalloproteinase domain-containing protein 17 is the right protein anchor across sources, using UniProt O77636 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDisintegrin and metalloproteinase domain-containing protein 17
UniProt AccessionO77636
Component TypeProtein
Sequence Length833 aa

Disintegrin and metalloproteinase domain-containing protein 17

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Disintegrin and metalloproteinase domain-containing protein 17, mapped to UniProt O77636. Sequence length is 833 aa.

Mapped IDO77636
Review nameDisintegrin and metalloproteinase domain-containing protein 17
OrganismSus scrofa
Assay Mix

Activity Type Distribution

IC50410.0
KI24.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL343548 10.18 IC50 0.066 Preclinical
CHEMBL271235 9.85 IC50 0.14 Preclinical
CHEMBL252893 9.82 Ki 0.15 Preclinical
CHEMBL137703 9.66 IC50 0.22 Preclinical
CHEMBL342687 9.59 IC50 0.26 Preclinical
CHEMBL137732 9.55 IC50 0.28 Preclinical
CHEMBL137065 9.51 IC50 0.31 Preclinical
CHEMBL207305 9.46 Ki 0.35 Preclinical
CHEMBL403401 9.4 IC50 0.4 Preclinical
CHEMBL137013 9.39 IC50 0.41 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
5
5.5
13
6.0
31
6.5
40
7.0
51
7.5
62
8.0
115
8.5
58
9.0
7
9.5
pChEMBL
Assay Landscape

Assay Landscape

28
Total Assays
350
Tested Compounds
1
Assay Types
Binding — 28 assays, 350 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 28 350 8.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine