Cytochrome P450 2B1 · SINGLE PROTEIN · Rattus norvegicus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P00176. Use UniProt P00176 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00176 as the stable identity anchor, then attach disease evidence before program review.
Cytochrome P450 2B1
Review this target as Cytochrome P450 2B1, mapped to UniProt P00176. Sequence length is 491 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Cytochrome P450 2B1 as ChEMBL target CHEMBL3335, mapped to UniProt P00176. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Cytochrome P450 2B1 |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P00176 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cytochrome P450 2B1 |
| UniProt Accession | P00176 |
| Component Type | Protein |
| Sequence Length | 491 aa |
Cytochrome P450 2B1
Review this target as Cytochrome P450 2B1, mapped to UniProt P00176. Sequence length is 491 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL1743361 | 7.1 | Ki | 80.0 | Preclinical |
| CHEMBL1908227 | 6.85 | Ki | 140.0 | Preclinical |
| CHEMBL1908228 | 6.1 | Ki | 800.0 | Preclinical |
| CHEMBL972 | 5.98 | Ki | 1050.0 | Approved |
| CHEMBL1275862 | 5.95 | Kd | 1120.0 | Preclinical |
| CHEMBL8706 | 5.82 | Ki | 1500.0 | Clinical |
| CHEMBL1078442 | 5.62 | Ki | 2400.0 | Preclinical |
| CHEMBL1908211 | 5.28 | Ki | 5200.0 | Preclinical |
| CHEMBL55285 | 5.24 | Ki | 5800.0 | Preclinical |
| CHEMBL14145 | 5.13 | IC50 | 7400.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 20 | 26 | 5.3 |
| assay format | 3 | 0 | — |
| microsome format | 3 | 82 | 4.5 |