Squalene synthase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Squalene synthase shows late clinical disease relevance led by Disorder of lipid metabolism. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P37268. Start with Disorder of lipid metabolism, then reuse UniProt P37268 as the stable protein anchor across project notes and exports.
Start with Disorder of lipid metabolism, then reuse UniProt P37268 as the stable protein anchor across project notes and exports.
Squalene synthase shows late clinical disease relevance led by Disorder of lipid metabolism. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with Disorder of lipid metabolism because it currently carries late clinical support. Linked drugs include LAPAQUISTAT ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySqualene synthase
Review this target as Squalene synthase, mapped to UniProt P37268. Sequence length is 417 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Squalene synthase as ChEMBL target CHEMBL3338, mapped to UniProt P37268. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Squalene synthase is the right protein anchor across sources, using UniProt P37268 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why Disorder of lipid metabolism is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Squalene synthase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P37268 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Squalene synthase |
| UniProt Accession | P37268 |
| Component Type | Protein |
| Sequence Length | 417 aa |
Squalene synthase
Review this target as Squalene synthase, mapped to UniProt P37268. Sequence length is 417 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Squalene synthase shows late clinical disease relevance led by Disorder of lipid metabolism. 3 more disease programs remain visible in the same review block.
Start review with Disorder of lipid metabolism because it currently carries late clinical support. Linked drugs include LAPAQUISTAT ACETATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL507677 | 9.7 | IC50 | 0.2 | Preclinical |
| CHEMBL40991 | 9.62 | IC50 | 0.24 | Preclinical |
| CHEMBL335394 | 9.55 | IC50 | 0.28 | Preclinical |
| CHEMBL436588 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL505374 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL1684849 | 9.35 | IC50 | 0.45 | Preclinical |
| CHEMBL61985 | 9.28 | IC50 | 0.52 | Preclinical |
| CHEMBL441322 | 9.19 | IC50 | 0.64 | Preclinical |
| CHEMBL2115091 | 9.14 | IC50 | 0.73 | Preclinical |
| CHEMBL1684826 | 9.07 | IC50 | 0.85 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 24 | 118 | 7.2 |
| assay format | 7 | 22 | 7.1 |
| cell-based format | 7 | 51 | 6.8 |
| microsome format | 2 | 7 | 7.4 |