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Target Snapshot

CHEMBL3341578 Target Snapshot

ATP-dependent Clp protease proteolytic subunit · SINGLE PROTEIN · Escherichia coli (strain K12)

150Compounds
22Assays
0Approved Drugs
125.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P0A6G7. Use UniProt P0A6G7 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P0A6G7 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats ATP-dependent Clp protease proteolytic subunit as ChEMBL target CHEMBL3341578, mapped to UniProt P0A6G7. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
ATP-dependent Clp protease proteolytic subunit
SINGLE PROTEIN · Escherichia coli (strain K12)
As of 2026-09-14
ChEMBL target ID
CHEMBL3341578
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P0A6G7
ATP-dependent Clp protease proteolytic subunit
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether ATP-dependent Clp protease proteolytic subunit is the right protein anchor across sources, using UniProt P0A6G7 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelATP-dependent Clp protease proteolytic subunit
UniProt AccessionP0A6G7
Component TypeProtein
Sequence Length207 aa

ATP-dependent Clp protease proteolytic subunit

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as ATP-dependent Clp protease proteolytic subunit, mapped to UniProt P0A6G7. Sequence length is 207 aa.

Mapped IDP0A6G7
Review nameATP-dependent Clp protease proteolytic subunit
OrganismEscherichia coli (strain K12)
Assay Mix

Activity Type Distribution

IC50107.0
EC5015.0
KD3.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4549588 7.0 EC50 100.0 Preclinical
CHEMBL5595943 6.7 EC50 200.0 Preclinical
CHEMBL5595943 6.57 Kd 270.0 Preclinical
CHEMBL3342324 6.52 Kd 300.0 Preclinical
CHEMBL4448860 6.3 IC50 500.0 Preclinical
CHEMBL4551942 6.3 IC50 500.0 Preclinical
CHEMBL4444802 6.22 IC50 600.0 Preclinical
CHEMBL4483092 6.22 IC50 600.0 Preclinical
CHEMBL3342325 6.16 Kd 700.0 Preclinical
CHEMBL5590180 5.75 EC50 1790.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
4
5.5
5
6.0
3
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

22
Total Assays
31
Tested Compounds
1
Assay Types
Binding — 22 assays, 31 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 20 22 5.2
assay format 2 9 5.6

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine