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Target Snapshot

CHEMBL3341584 Target Snapshot

G-protein coupled receptor 39 · SINGLE PROTEIN · Mus musculus

27Compounds
7Assays
0Approved Drugs
28.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q5U431. Use UniProt Q5U431 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5U431 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats G-protein coupled receptor 39 as ChEMBL target CHEMBL3341584, mapped to UniProt Q5U431. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
G-protein coupled receptor 39
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3341584
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q5U431
G-protein coupled receptor 39
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether G-protein coupled receptor 39 is the right protein anchor across sources, using UniProt Q5U431 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelG-protein coupled receptor 39
UniProt AccessionQ5U431
Component TypeProtein
Sequence Length456 aa

G-protein coupled receptor 39

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as G-protein coupled receptor 39, mapped to UniProt Q5U431. Sequence length is 456 aa.

Mapped IDQ5U431
Review nameG-protein coupled receptor 39
OrganismMus musculus
Assay Mix

Activity Type Distribution

EC5028.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3342370 9.3 EC50 0.5 Preclinical
CHEMBL3342371 9.0 EC50 1.0 Preclinical
CHEMBL3342377 8.7 EC50 2.0 Preclinical
CHEMBL4100119 8.59 EC50 2.6 Preclinical
CHEMBL3341764 8.52 EC50 3.0 Preclinical
CHEMBL3342367 8.52 EC50 3.0 Preclinical
CHEMBL3342357 8.4 EC50 4.0 Preclinical
CHEMBL4077818 8.3 EC50 5.0 Preclinical
CHEMBL3342374 8.15 EC50 7.0 Preclinical
CHEMBL3342376 8.1 EC50 8.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
2
5.5
2
6.0
4
6.5
1
7.0
2
7.5
6
8.0
4
8.5
2
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

7
Total Assays
25
Tested Compounds
2
Assay Types
Functional — 5 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 3 23 7.2
assay format 1 0
single protein format 1 2 8.5
Binding — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine