Tyrosine-protein phosphatase non-receptor type 1 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P18031. Use UniProt P18031 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P18031 as the stable identity anchor, then attach disease evidence before program review.
Tyrosine-protein phosphatase non-receptor type 1
Review this target as Tyrosine-protein phosphatase non-receptor type 1, mapped to UniProt P18031. Sequence length is 435 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Tyrosine-protein phosphatase non-receptor type 1 as ChEMBL target CHEMBL335, mapped to UniProt P18031. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Tyrosine-protein phosphatase non-receptor type 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P18031 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Tyrosine-protein phosphatase non-receptor type 1 |
| UniProt Accession | P18031 |
| Component Type | Protein |
| Sequence Length | 435 aa |
Tyrosine-protein phosphatase non-receptor type 1
Review this target as Tyrosine-protein phosphatase non-receptor type 1, mapped to UniProt P18031. Sequence length is 435 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL444092 | 10.0 | IC50 | 0.1 | Preclinical |
| CHEMBL430266 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL4524071 | 9.38 | IC50 | 0.42 | Preclinical |
| CHEMBL5619806 | 9.2 | IC50 | 0.63 | Preclinical |
| CHEMBL244563 | 9.17 | Ki | 0.68 | Preclinical |
| CHEMBL505512 | 9.17 | IC50 | 0.67 | Preclinical |
| CHEMBL5095164 | 9.16 | IC50 | 0.69 | Clinical |
| CHEMBL184444 | 9.04 | Ki | 0.92 | Preclinical |
| CHEMBL5076419 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5085615 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 783 | 2,967 | 5.5 |
| assay format | 247 | 826 | 5.3 |
| cell-based format | 94 | 143 | 5.6 |
| tissue-based format | 2 | 3 | 9.3 |
| organism-based format | 1 | 28 | 5.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 8 | 0 | — |
| assay format | 2 | 13 | 4.3 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 1 | 5.7 |
| assay format | 1 | 6 | 4.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 19 | 6.0 |