Hepatocyte growth factor activator · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q04756. Use UniProt Q04756 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q04756 as the stable identity anchor, then attach disease evidence before program review.
Hepatocyte growth factor activator serine protease
Review this target as Hepatocyte growth factor activator, mapped to UniProt Q04756. ChEMBL maps the protein component as Hepatocyte growth factor activator serine protease. Sequence length is 655 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Hepatocyte growth factor activator as ChEMBL target CHEMBL3351190, mapped to UniProt Q04756. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Hepatocyte growth factor activator |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q04756 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Hepatocyte growth factor activator serine protease |
| UniProt Accession | Q04756 |
| Component Type | Protein |
| Sequence Length | 655 aa |
Hepatocyte growth factor activator serine protease
Review this target as Hepatocyte growth factor activator, mapped to UniProt Q04756. ChEMBL maps the protein component as Hepatocyte growth factor activator serine protease. Sequence length is 655 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4464524 | 8.43 | Ki | 3.7 | Preclinical |
| CHEMBL5560415 | 8.34 | IC50 | 4.6 | Preclinical |
| CHEMBL4587327 | 8.14 | Ki | 7.2 | Preclinical |
| CHEMBL3356596 | 7.92 | Ki | 12.0 | Preclinical |
| CHEMBL5564865 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL3356606 | 7.77 | Ki | 17.0 | Preclinical |
| CHEMBL3356597 | 7.68 | Ki | 21.0 | Preclinical |
| CHEMBL3356603 | 7.62 | Ki | 24.0 | Preclinical |
| CHEMBL273264 | 7.6 | Ki | 25.0 | Clinical |
| CHEMBL5074750 | 7.58 | IC50 | 26.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 10 | 76 | 6.2 |
| cell-based format | 7 | 37 | 5.7 |