Neprilysin · SINGLE PROTEIN · Rattus norvegicus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P07861. Use UniProt P07861 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P07861 as the stable identity anchor, then attach disease evidence before program review.
Neprilysin
Review this target as Neprilysin, mapped to UniProt P07861. Sequence length is 750 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Neprilysin as ChEMBL target CHEMBL3369, mapped to UniProt P07861. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Neprilysin is the right protein anchor across sources, using UniProt P07861 as the stable mapping.
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| Preferred Name | Neprilysin |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P07861 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Neprilysin |
| UniProt Accession | P07861 |
| Component Type | Protein |
| Sequence Length | 750 aa |
Neprilysin
Review this target as Neprilysin, mapped to UniProt P07861. Sequence length is 750 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL353341 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL5283332 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL78429 | 10.15 | Ki | 0.07 | Preclinical |
| CHEMBL5277842 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL63123 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL154588 | 9.57 | IC50 | 0.27 | Preclinical |
| CHEMBL294536 | 9.52 | Ki | 0.3 | Preclinical |
| CHEMBL304233 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL366495 | 9.4 | Ki | 0.4 | Preclinical |
| CHEMBL165980 | 9.39 | IC50 | 0.41 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 53 | 313 | 7.4 |
| cell membrane format | 5 | 29 | 7.4 |
| assay format | 4 | 22 | 7.0 |
| tissue-based format | 3 | 15 | 8.1 |
| organism-based format | 2 | 1 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 2 | 10 | 8.8 |
| organism-based format | 1 | 0 | — |