Thermolysin · SINGLE PROTEIN · Bacillus thermoproteolyticus
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-14Protein identity stays anchored to UniProt P00800. Use UniProt P00800 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P00800 as the stable identity anchor, then attach disease evidence before program review.
Thermolysin
Review this target as Thermolysin, mapped to UniProt P00800. Sequence length is 548 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Thermolysin as ChEMBL target CHEMBL3392, mapped to UniProt P00800. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Thermolysin is the right protein anchor across sources, using UniProt P00800 as the stable mapping.
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| Preferred Name | Thermolysin |
| Target Type | SINGLE PROTEIN |
| Organism | Bacillus thermoproteolyticus |
| UniProt | P00800 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Thermolysin |
| UniProt Accession | P00800 |
| Component Type | Protein |
| Sequence Length | 548 aa |
Thermolysin
Review this target as Thermolysin, mapped to UniProt P00800. Sequence length is 548 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL459183 | 10.19 | IC50 | 0.06397 | Preclinical |
| CHEMBL459183 | 10.19 | Ki | 0.064 | Preclinical |
| CHEMBL43341 | 10.17 | Ki | 0.06761 | Preclinical |
| CHEMBL44737 | 10.17 | Ki | 0.068 | Preclinical |
| CHEMBL38873 | 8.82 | Ki | 1.514 | Preclinical |
| CHEMBL303892 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL85320 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL3409520 | 8.31 | Ki | 4.9 | Preclinical |
| CHEMBL303159 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL66967 | 8.3 | IC50 | 5.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 44 | 219 | 6.0 |