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Target Snapshot

CHEMBL3395 Target Snapshot

Glutamate receptor ionotropic kainate 2 · SINGLE PROTEIN · Xenopus laevis

3Compounds
4Assays
0Approved Drugs
6.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt B9V8S1. Use UniProt B9V8S1 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt B9V8S1 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutamate receptor ionotropic kainate 2 as ChEMBL target CHEMBL3395, mapped to UniProt B9V8S1. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutamate receptor ionotropic kainate 2
SINGLE PROTEIN · Xenopus laevis
As of 2026-09-14
ChEMBL target ID
CHEMBL3395
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
B9V8S1
Glutamate receptor
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutamate receptor ionotropic kainate 2 is the right protein anchor across sources, using UniProt B9V8S1 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutamate receptor
UniProt AccessionB9V8S1
Component TypeProtein
Sequence Length908 aa

Glutamate receptor

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Glutamate receptor ionotropic kainate 2, mapped to UniProt B9V8S1. ChEMBL maps the protein component as Glutamate receptor. Sequence length is 908 aa.

Mapped IDB9V8S1
Review nameGlutamate receptor ionotropic kainate 2
OrganismXenopus laevis
Assay Mix

Activity Type Distribution

EC506.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL29024 5.31 EC50 4900.0 Preclinical
CHEMBL28472 5.19 EC50 6400.0 Preclinical
CHEMBL27130 4.21 EC50 61000.0 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

4
Total Assays
3
Tested Compounds
1
Assay Types
Binding — 4 assays, 3 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 3 4.9

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine