DNA topoisomerase 2-beta · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt Q02880. Use UniProt Q02880 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q02880 as the stable identity anchor, then attach disease evidence before program review.
DNA topoisomerase 2-beta
Review this target as DNA topoisomerase 2-beta, mapped to UniProt Q02880. Sequence length is 1626 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA topoisomerase 2-beta as ChEMBL target CHEMBL3396, mapped to UniProt Q02880. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA topoisomerase 2-beta is the right protein anchor across sources, using UniProt Q02880 as the stable mapping.
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| Preferred Name | DNA topoisomerase 2-beta |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q02880 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA topoisomerase 2-beta |
| UniProt Accession | Q02880 |
| Component Type | Protein |
| Sequence Length | 1626 aa |
DNA topoisomerase 2-beta
Review this target as DNA topoisomerase 2-beta, mapped to UniProt Q02880. Sequence length is 1626 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4161876 | 8.16 | IC50 | 6.85 | Preclinical |
| CHEMBL4174756 | 7.9 | IC50 | 12.6 | Preclinical |
| CHEMBL5266387 | 7.59 | IC50 | 25.8 | Preclinical |
| CHEMBL49442 | 7.52 | IC50 | 30.0 | Clinical |
| CHEMBL4160802 | 7.5 | IC50 | 31.68 | Preclinical |
| CHEMBL44657 | 7.16 | IC50 | 69.8 | Approved |
| CHEMBL4172196 | 7.09 | IC50 | 81.42 | Preclinical |
| CHEMBL4169404 | 6.96 | IC50 | 110.45 | Preclinical |
| CHEMBL4751362 | 6.89 | IC50 | 130.0 | Preclinical |
| CHEMBL3039513 | 6.83 | Kd | 148.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 65 | 32 | 5.9 |
| assay format | 11 | 1 | — |
| cell-based format | 10 | 0 | — |
| tissue-based format | 3 | 0 | — |
| subcellular format | 1 | 3 | 6.2 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 24 | 0 | — |