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Target Snapshot

CHEMBL3399914 Target Snapshot

AGAP002992-PA · SINGLE PROTEIN · Anopheles gambiae

40Compounds
1Assays
12Approved Drugs
40.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt Q5TU56. Use UniProt Q5TU56 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q5TU56 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats AGAP002992-PA as ChEMBL target CHEMBL3399914, mapped to UniProt Q5TU56. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
AGAP002992-PA
SINGLE PROTEIN · Anopheles gambiae
As of 2026-09-13
ChEMBL target ID
CHEMBL3399914
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
Q5TU56
Carbonic anhydrase
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether AGAP002992-PA is the right protein anchor across sources, using UniProt Q5TU56 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelCarbonic anhydrase
UniProt AccessionQ5TU56
Component TypeProtein
Sequence Length255 aa

Carbonic anhydrase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as AGAP002992-PA, mapped to UniProt Q5TU56. ChEMBL maps the protein component as Carbonic anhydrase. Sequence length is 255 aa.

Mapped IDQ5TU56
Review nameAGAP002992-PA
OrganismAnopheles gambiae
Clinical Profile

Clinical Phase Distribution

12
Approved
4
Phase III
2
Phase II
Assay Mix

Activity Type Distribution

KI40.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL2324864 8.21 Ki 6.1 Preclinical
CHEMBL268439 8.17 Ki 6.8 Preclinical
CHEMBL73962 8.01 Ki 9.8 Preclinical
CHEMBL20 7.56 Ki 27.3 Approved
CHEMBL26 7.53 Ki 29.5 Clinical
CHEMBL435 7.5 Ki 31.5 Approved
CHEMBL220491 7.5 Ki 31.4 Approved
CHEMBL7146 7.33 Ki 47.0 Preclinical
CHEMBL266026 7.09 Ki 81.9 Preclinical
CHEMBL269122 7.08 Ki 83.4 Preclinical
Distribution

pChEMBL Value Distribution

2
5.0
1
5.5
10
6.0
8
6.5
4
7.0
4
7.5
3
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

VALDECOXIB
CHEMBL865
Approved 2001
ZONISAMIDE
CHEMBL750
Approved 2000
BRINZOLAMIDE
CHEMBL220491
Approved 1998
CELECOXIB
CHEMBL118
Approved 1998
DORZOLAMIDE
CHEMBL218490
Approved 1994
SULFANILAMIDE
CHEMBL21
Approved 1985
ETHOXZOLAMIDE
CHEMBL18
Approved 1982
HYDROCHLOROTHIAZIDE
CHEMBL435
Approved 1959
METHAZOLAMIDE
CHEMBL19
Approved 1959
DICHLORPHENAMIDE
CHEMBL17
Approved 1958
ACETAZOLAMIDE
CHEMBL20
Approved 1953
Assay Landscape

Assay Landscape

1
Total Assays
36
Tested Compounds
1
Assay Types
Binding — 1 assays, 36 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 36 6.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine