Butyrylcholinesterase · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt Q9JKC1. Use UniProt Q9JKC1 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q9JKC1 as the stable identity anchor, then attach disease evidence before program review.
Carboxylic ester hydrolase
Review this target as Butyrylcholinesterase, mapped to UniProt Q9JKC1. ChEMBL maps the protein component as Carboxylic ester hydrolase. Sequence length is 597 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Butyrylcholinesterase as ChEMBL target CHEMBL3403, mapped to UniProt Q9JKC1. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Butyrylcholinesterase |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | Q9JKC1 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Carboxylic ester hydrolase |
| UniProt Accession | Q9JKC1 |
| Component Type | Protein |
| Sequence Length | 597 aa |
Carboxylic ester hydrolase
Review this target as Butyrylcholinesterase, mapped to UniProt Q9JKC1. ChEMBL maps the protein component as Carboxylic ester hydrolase. Sequence length is 597 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL521589 | 8.52 | IC50 | 3.0 | Clinical |
| CHEMBL340625 | 8.44 | IC50 | 3.6 | Preclinical |
| CHEMBL74950 | 8.24 | IC50 | 5.8 | Preclinical |
| CHEMBL94 | 8.12 | IC50 | 7.6 | Clinical |
| CHEMBL3321889 | 8.1 | IC50 | 8.0 | Preclinical |
| CHEMBL1082185 | 8.07 | IC50 | 8.5 | Preclinical |
| CHEMBL95 | 8.05 | IC50 | 9.0 | Approved |
| CHEMBL3321877 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL3321887 | 7.92 | IC50 | 12.0 | Preclinical |
| CHEMBL184784 | 7.91 | IC50 | 12.4 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 38 | 146 | 5.9 |
| cell-free format | 19 | 176 | 5.4 |
| assay format | 9 | 34 | 5.0 |
| organism-based format | 2 | 0 | — |
| tissue-based format | 2 | 1 | 4.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-free format | 4 | 2 | 4.8 |
| single protein format | 3 | 7 | 4.6 |
| assay format | 2 | 1 | 4.4 |