6-phosphogluconate dehydrogenase, decarboxylating · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P52209. Use UniProt P52209 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P52209 as the stable identity anchor, then attach disease evidence before program review.
6-phosphogluconate dehydrogenase, decarboxylating
Review this target as 6-phosphogluconate dehydrogenase, decarboxylating, mapped to UniProt P52209. Sequence length is 483 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 6-phosphogluconate dehydrogenase, decarboxylating as ChEMBL target CHEMBL3404, mapped to UniProt P52209. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | 6-phosphogluconate dehydrogenase, decarboxylating |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P52209 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 6-phosphogluconate dehydrogenase, decarboxylating |
| UniProt Accession | P52209 |
| Component Type | Protein |
| Sequence Length | 483 aa |
6-phosphogluconate dehydrogenase, decarboxylating
Review this target as 6-phosphogluconate dehydrogenase, decarboxylating, mapped to UniProt P52209. Sequence length is 483 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL116018 | 8.0 | Ki | 10.0 | Preclinical |
| CHEMBL324609 | 7.46 | Ki | 35.0 | Preclinical |
| CHEMBL114269 | 7.1 | Ki | 80.0 | Preclinical |
| CHEMBL1160945 | 6.89 | Ki | 130.0 | Preclinical |
| CHEMBL5653589 | 6.88 | Kd | 130.78 | Preclinical |
| CHEMBL36327 | 6.68 | IC50 | 210.0 | Preclinical |
| CHEMBL297453 | 6.14 | IC50 | 720.0 | Clinical |
| CHEMBL129451 | 5.89 | IC50 | 1280.0 | Preclinical |
| CHEMBL264938 | 5.84 | IC50 | 1450.0 | Preclinical |
| CHEMBL323922 | 5.82 | Ki | 1520.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 10 | 0 | — |
| assay format | 4 | 11 | 5.9 |
| single protein format | 4 | 6 | 6.0 |