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Target Snapshot

CHEMBL3407321 Target Snapshot

Neurogenic locus notch homolog protein 4 · SINGLE PROTEIN · Homo sapiens

1Compounds
1Assays
0Approved Drugs
1.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q99466. Use UniProt Q99466 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q99466 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Neurogenic locus notch homolog protein 4 as ChEMBL target CHEMBL3407321, mapped to UniProt Q99466. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Neurogenic locus notch homolog protein 4
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3407321
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q99466
Neurogenic locus notch homolog protein 4
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Neurogenic locus notch homolog protein 4 is the right protein anchor across sources, using UniProt Q99466 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelNeurogenic locus notch homolog protein 4
UniProt AccessionQ99466
Component TypeProtein
Sequence Length2003 aa

Neurogenic locus notch homolog protein 4

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Neurogenic locus notch homolog protein 4, mapped to UniProt Q99466. Sequence length is 2003 aa.

Mapped IDQ99466
Review nameNeurogenic locus notch homolog protein 4
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC501.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3410161 8.52 IC50 3.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
0
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

1
Total Assays
1
Tested Compounds
1
Assay Types
Binding — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 1 1 8.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine