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Target Snapshot

CHEMBL341 Target Snapshot

Gamma-aminobutyric acid receptor subunit alpha-2 · SINGLE PROTEIN · Rattus norvegicus

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76Compounds
15Assays
2Approved Drugs
26.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P23576. Use UniProt P23576 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P23576 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Gamma-aminobutyric acid receptor subunit alpha-2 as ChEMBL target CHEMBL341, mapped to UniProt P23576. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Gamma-aminobutyric acid receptor subunit alpha-2
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-13
ChEMBL target ID
CHEMBL341
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P23576
Gamma-aminobutyric acid receptor subunit alpha-2
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Gamma-aminobutyric acid receptor subunit alpha-2 is the right protein anchor across sources, using UniProt P23576 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameGamma-aminobutyric acid receptor subunit alpha-2
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP23576
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGamma-aminobutyric acid receptor subunit alpha-2
UniProt AccessionP23576
Component TypeProtein
Sequence Length451 aa

Gamma-aminobutyric acid receptor subunit alpha-2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Gamma-aminobutyric acid receptor subunit alpha-2, mapped to UniProt P23576. Sequence length is 451 aa.

Mapped IDP23576
Review nameGamma-aminobutyric acid receptor subunit alpha-2
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC501.0
KI25.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5272250 7.92 Ki 12.0 Preclinical
CHEMBL12 7.82 Ki 15.0 Approved
CHEMBL96 7.66 IC50 22.0 Preclinical
CHEMBL521901 7.07 Ki 85.0 Preclinical
CHEMBL127135 6.93 Ki 118.0 Preclinical
CHEMBL75456 6.92 Ki 121.0 Preclinical
CHEMBL911 6.81 Ki 156.0 Approved
CHEMBL74302 6.68 Ki 210.0 Preclinical
CHEMBL495634 6.64 Ki 231.0 Preclinical
CHEMBL495616 6.29 Ki 513.0 Preclinical
Distribution

pChEMBL Value Distribution

1
5.0
5
5.5
5
6.0
5
6.5
1
7.0
4
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

ZOLPIDEM
CHEMBL911
Approved 1992
Properties Compare Identifier
DIAZEPAM
CHEMBL12
Approved 1963
Properties Compare Identifier
Assay Landscape

Assay Landscape

15
Total Assays
20
Tested Compounds
2
Assay Types
Binding — 11 assays, 20 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 4 0 —
cell-based format 3 16 6.4
single protein format 3 3 5.8
assay format 1 1 7.7
Functional — 4 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 2 0 —
cell-based format 1 0 —
tissue-based format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine