Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P54750. Use UniProt P54750 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P54750 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Review this target as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, mapped to UniProt P54750. Sequence length is 535 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A as ChEMBL target CHEMBL3421, mapped to UniProt P54750. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P54750 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A |
| UniProt Accession | P54750 |
| Component Type | Protein |
| Sequence Length | 535 aa |
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A
Review this target as Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1A, mapped to UniProt P54750. Sequence length is 535 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3678507 | 10.0 | Ki | 0.1 | Preclinical |
| CHEMBL5843142 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL5872664 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL5959210 | 9.85 | IC50 | 0.14 | Preclinical |
| CHEMBL3678504 | 9.7 | Ki | 0.2 | Preclinical |
| CHEMBL6042932 | 9.67 | IC50 | 0.214 | Preclinical |
| CHEMBL5874788 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL5912826 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL5977186 | 9.59 | IC50 | 0.26 | Preclinical |
| CHEMBL3678506 | 9.52 | Ki | 0.3 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 76 | 627 | 7.4 |
| cell-based format | 21 | 13 | 8.3 |
| assay format | 5 | 9 | 8.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 2 | 5.6 |
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 2 | 6.9 |