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Target Snapshot

CHEMBL3422 Target Snapshot

3-oxo-5-alpha-steroid 4-dehydrogenase 1 · SINGLE PROTEIN · Rattus norvegicus

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182Compounds
26Assays
2Approved Drugs
99.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P24008. Use UniProt P24008 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P24008 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 3-oxo-5-alpha-steroid 4-dehydrogenase 1 as ChEMBL target CHEMBL3422, mapped to UniProt P24008. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
3-oxo-5-alpha-steroid 4-dehydrogenase 1
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3422
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P24008
3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 3-oxo-5-alpha-steroid 4-dehydrogenase 1 is the right protein anchor across sources, using UniProt P24008 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred Name3-oxo-5-alpha-steroid 4-dehydrogenase 1
Target TypeSINGLE PROTEIN
OrganismRattus norvegicus
UniProtP24008
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label3-oxo-5-alpha-steroid 4-dehydrogenase 1
UniProt AccessionP24008
Component TypeProtein
Sequence Length259 aa

3-oxo-5-alpha-steroid 4-dehydrogenase 1

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 3-oxo-5-alpha-steroid 4-dehydrogenase 1, mapped to UniProt P24008. Sequence length is 259 aa.

Mapped IDP24008
Review name3-oxo-5-alpha-steroid 4-dehydrogenase 1
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

2
Approved
2
Phase II
Assay Mix

Activity Type Distribution

IC5093.0
KI6.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL314953 10.15 Ki 0.07 Preclinical
CHEMBL277224 10.0 Ki 0.1 Preclinical
CHEMBL327702 9.57 Ki 0.27 Preclinical
CHEMBL90085 9.32 IC50 0.48 Preclinical
CHEMBL710 8.38 IC50 4.2 Approved
CHEMBL710 8.17 Ki 6.8 Approved
CHEMBL24955 8.1 Ki 8.0 Clinical
CHEMBL4540042 7.82 IC50 15.0 Preclinical
CHEMBL4569322 7.47 IC50 34.0 Preclinical
CHEMBL3138301 7.46 Ki 35.0 Preclinical
Distribution

pChEMBL Value Distribution

10
5.0
9
5.5
2
6.0
3
6.5
3
7.0
2
7.5
4
8.0
0
8.5
1
9.0
1
9.5
pChEMBL
Approved Drugs

Approved Drugs

FINASTERIDE
CHEMBL710
Approved 1992
Properties Compare Identifier
Assay Landscape

Assay Landscape

26
Total Assays
43
Tested Compounds
2
Assay Types
Binding — 24 assays, 43 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 10 8 8.8
assay format 9 20 5.8
tissue-based format 3 11 5.9
microsome format 2 4 5.6
Functional — 2 assays, 13 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 2 13 5.2

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine