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Target Snapshot

CHEMBL3430879 Target Snapshot

Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha · PROTEIN COMPLEX · Homo sapiens

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94Compounds
17Assays
0Approved Drugs
72.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Protein identity stays anchored to UniProt P19793. Use UniProt P19793 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P19793 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha as ChEMBL target CHEMBL3430879, mapped to UniProt P19793. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-13
ChEMBL target ID
CHEMBL3430879
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
UniProt accession
P19793
Retinoic acid receptor RXR-alpha
UniProt accession via ChEMBL component mapping As of 2026-09-13
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha is the right protein anchor across sources, using UniProt P19793 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameRetinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP19793
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelRetinoic acid receptor RXR-alpha
UniProt AccessionP19793
Component TypeProtein
Sequence Length462 aa

Retinoic acid receptor RXR-alpha

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Retinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha, mapped to UniProt P19793. ChEMBL maps the protein component as Retinoic acid receptor RXR-alpha. Sequence length is 462 aa.

Mapped IDP19793
Review nameRetinoic acid receptor RXR-alpha/oxysterols receptor LXR-alpha
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

3
Phase I
Assay Mix

Activity Type Distribution

KI44.0
EC5026.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4764328 10.1 EC50 0.08 Preclinical
CHEMBL62136 10.01 EC50 0.098 Preclinical
CHEMBL4756418 9.84 EC50 0.145 Preclinical
CHEMBL4745005 9.79 EC50 0.161 Preclinical
CHEMBL4764838 9.76 EC50 0.174 Preclinical
CHEMBL4747448 9.67 EC50 0.214 Preclinical
CHEMBL4749385 9.6 EC50 0.251 Preclinical
CHEMBL4762546 9.57 EC50 0.27 Preclinical
CHEMBL4797369 9.57 EC50 0.27 Preclinical
CHEMBL4757761 9.56 EC50 0.274 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
3
5.5
2
6.0
10
6.5
14
7.0
9
7.5
1
8.0
5
8.5
7
9.0
9
9.5
pChEMBL
Assay Landscape

Assay Landscape

17
Total Assays
42
Tested Compounds
3
Assay Types
Binding — 11 assays, 42 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 6 33 7.1
protein complex format 5 9 5.9
ADME — 4 assays, 25 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 4 25 9.0
Functional — 2 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 2 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine