PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P48736. Use UniProt P48736 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P48736 as the stable identity anchor, then attach disease evidence before program review.
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Review this target as PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5, mapped to UniProt P48736. ChEMBL maps the protein component as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. Sequence length is 1102 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5 as ChEMBL target CHEMBL3430881, mapped to UniProt P48736. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P48736 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform |
| UniProt Accession | P48736 |
| Component Type | Protein |
| Sequence Length | 1102 aa |
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform
Review this target as PI3-kinase subunit gamma/Phosphoinositide 3-kinase regulatory subunit 5, mapped to UniProt P48736. ChEMBL maps the protein component as Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit gamma isoform. Sequence length is 1102 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3612310 | 7.96 | IC50 | 11.0 | Preclinical |
| CHEMBL1879463 | 7.14 | IC50 | 72.0 | Clinical |
| CHEMBL4555071 | 7.1 | IC50 | 80.0 | Preclinical |
| CHEMBL4097625 | 6.94 | IC50 | 116.0 | Preclinical |
| CHEMBL521851 | 6.93 | IC50 | 117.0 | Clinical |
| CHEMBL2017974 | 6.89 | IC50 | 129.0 | Clinical |
| CHEMBL4446205 | 6.8 | IC50 | 158.0 | Preclinical |
| CHEMBL4088969 | 6.74 | IC50 | 181.0 | Preclinical |
| CHEMBL3416181 | 6.41 | IC50 | 394.0 | Preclinical |
| CHEMBL3416184 | 6.33 | IC50 | 465.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 4 | 10 | 6.9 |