Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O94782. Use UniProt O94782 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O94782 as the stable identity anchor, then attach disease evidence before program review.
Ubiquitin carboxyl-terminal hydrolase 1
Review this target as Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48, mapped to UniProt O94782. ChEMBL maps the protein component as Ubiquitin carboxyl-terminal hydrolase 1. Sequence length is 785 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 as ChEMBL target CHEMBL3430885, mapped to UniProt O94782. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | O94782 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Ubiquitin carboxyl-terminal hydrolase 1 |
| UniProt Accession | O94782 |
| Component Type | Protein |
| Sequence Length | 785 aa |
Ubiquitin carboxyl-terminal hydrolase 1
Review this target as Ubiquitin carboxyl-terminal hydrolase 1/WD repeat-containing protein 48, mapped to UniProt O94782. ChEMBL maps the protein component as Ubiquitin carboxyl-terminal hydrolase 1. Sequence length is 785 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5593758 | 8.15 | IC50 | 7.1 | Preclinical |
| CHEMBL5595820 | 8.15 | Ki | 7.0 | Preclinical |
| CHEMBL5595820 | 8.06 | IC50 | 8.8 | Preclinical |
| CHEMBL5593526 | 7.95 | IC50 | 11.2 | Preclinical |
| CHEMBL5583831 | 7.88 | IC50 | 13.1 | Preclinical |
| CHEMBL5592698 | 7.79 | IC50 | 16.1 | Preclinical |
| CHEMBL3182437 | 7.77 | IC50 | 17.0 | Preclinical |
| CHEMBL5594891 | 7.73 | IC50 | 18.8 | Preclinical |
| CHEMBL5095186 | 7.67 | IC50 | 21.3 | Preclinical |
| CHEMBL5595458 | 7.64 | IC50 | 22.8 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| protein complex format | 16 | 150 | 6.2 |
| cell-based format | 10 | 1 | 5.5 |