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Target Snapshot

CHEMBL3430892 Target Snapshot

Integrin alpha-V/beta-8 · PROTEIN COMPLEX · Homo sapiens

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215Compounds
28Assays
0Approved Drugs
241.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Integrin alpha-V/beta-8 shows clinical signal disease relevance led by interstitial lung disease. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P06756. Start with interstitial lung disease, then reuse UniProt P06756 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with interstitial lung disease, then reuse UniProt P06756 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
interstitial lung disease

Integrin alpha-V/beta-8 shows clinical signal disease relevance led by interstitial lung disease. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with interstitial lung disease because it currently carries clinical signal support. Linked drugs include ABITUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Clinical signal Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Integrin alpha-V/beta-8 as ChEMBL target CHEMBL3430892, mapped to UniProt P06756. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Integrin alpha-V/beta-8
PROTEIN COMPLEX · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3430892
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P06756
Integrin alpha-V
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Integrin alpha-V/beta-8 is the right protein anchor across sources, using UniProt P06756 as the stable mapping.

Jump to Protein Context
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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why interstitial lung disease is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameIntegrin alpha-V/beta-8
Target TypePROTEIN COMPLEX
OrganismHomo sapiens
UniProtP06756
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelIntegrin alpha-V
UniProt AccessionP06756
Component TypeProtein
Sequence Length1048 aa

Integrin alpha-V

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Integrin alpha-V/beta-8, mapped to UniProt P06756. ChEMBL maps the protein component as Integrin alpha-V. Sequence length is 1048 aa.

Mapped IDP06756
Review nameIntegrin alpha-V/beta-8
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Clinical signal Open Targets-ready proxy

Integrin alpha-V/beta-8 shows clinical signal disease relevance led by interstitial lung disease. 4 more disease programs remain visible in the same review block.

Clinical signal Phase II
interstitial lung disease
1 linked drug · 1 direct · 1 efficacy
Linked drugABITUZUMAB
Clinical signal Phase II
prostate cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugABITUZUMAB
Clinical signal Phase II
systemic scleroderma
1 linked drug · 1 direct · 1 efficacy
Linked drugABITUZUMAB
Clinical signal Phase I
colorectal carcinoma
1 linked drug · 1 direct · 1 efficacy
Linked drugABITUZUMAB
Clinical signal Phase I
ovarian cancer
1 linked drug · 1 direct · 1 efficacy
Linked drugABITUZUMAB
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with interstitial lung disease because it currently carries clinical signal support. Linked drugs include ABITUZUMAB. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseaseinterstitial lung disease
Strongest levelClinical signal
Block modeOpen Targets-ready proxy
Clinical Profile

Clinical Phase Distribution

1
Phase II
4
Phase I
Assay Mix

Activity Type Distribution

IC50239.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL4443665 10.22 IC50 0.06 Preclinical
CHEMBL3319237 9.7 IC50 0.2 Preclinical
CHEMBL5914164 9.7 IC50 0.2 Preclinical
CHEMBL5748399 9.52 IC50 0.3 Preclinical
CHEMBL5770209 9.52 IC50 0.3 Preclinical
CHEMBL5781301 9.52 IC50 0.3 Preclinical
CHEMBL5786200 9.52 IC50 0.3 Preclinical
CHEMBL5964326 9.52 IC50 0.3 Preclinical
CHEMBL5980310 9.52 IC50 0.3 Preclinical
CHEMBL5889173 9.4 IC50 0.4 Preclinical
Distribution

pChEMBL Value Distribution

14
5.0
13
5.5
25
6.0
27
6.5
28
7.0
27
7.5
37
8.0
14
8.5
19
9.0
15
9.5
pChEMBL
Assay Landscape

Assay Landscape

28
Total Assays
197
Tested Compounds
2
Assay Types
Binding — 27 assays, 197 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 15 80 7.0
protein complex format 9 116 7.8
assay format 3 1 8.9
ADME — 1 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
protein complex format 1 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine