Integrin alpha-V/alpha-5 · PROTEIN COMPLEX · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P06756. Use UniProt P06756 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P06756 as the stable identity anchor, then attach disease evidence before program review.
Integrin alpha-V
Review this target as Integrin alpha-V/alpha-5, mapped to UniProt P06756. ChEMBL maps the protein component as Integrin alpha-V. Sequence length is 1048 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Integrin alpha-V/alpha-5 as ChEMBL target CHEMBL3430893, mapped to UniProt P06756. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Integrin alpha-V/alpha-5 is the right protein anchor across sources, using UniProt P06756 as the stable mapping.
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| Preferred Name | Integrin alpha-V/alpha-5 |
| Target Type | PROTEIN COMPLEX |
| Organism | Homo sapiens |
| UniProt | P06756 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Integrin alpha-V |
| UniProt Accession | P06756 |
| Component Type | Protein |
| Sequence Length | 1048 aa |
Integrin alpha-V
Review this target as Integrin alpha-V/alpha-5, mapped to UniProt P06756. ChEMBL maps the protein component as Integrin alpha-V. Sequence length is 1048 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL429876 | 9.89 | IC50 | 0.13 | Clinical |
| CHEMBL5790208 | 9.4 | IC50 | 0.4 | Preclinical |
| CHEMBL5914164 | 9.15 | IC50 | 0.7 | Preclinical |
| CHEMBL460012 | 9.05 | IC50 | 0.9 | Preclinical |
| CHEMBL5786200 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5889173 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5920684 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL5951981 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL244434 | 8.82 | IC50 | 1.5 | Preclinical |
| CHEMBL5748399 | 8.7 | IC50 | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 4 | 8.6 |
| cell-based format | 1 | 2 | 8.3 |
| protein complex format | 1 | 28 | 8.4 |