DNA gyrase subunit A/DNA gyrase subunit B · PROTEIN COMPLEX · Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv)
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As of 2026-09-14Protein identity stays anchored to UniProt P9WG45. Use UniProt P9WG45 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P9WG45 as the stable identity anchor, then attach disease evidence before program review.
DNA gyrase subunit B
Review this target as DNA gyrase subunit A/DNA gyrase subunit B, mapped to UniProt P9WG45. ChEMBL maps the protein component as DNA gyrase subunit B. Sequence length is 675 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats DNA gyrase subunit A/DNA gyrase subunit B as ChEMBL target CHEMBL3430898, mapped to UniProt P9WG45. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether DNA gyrase subunit A/DNA gyrase subunit B is the right protein anchor across sources, using UniProt P9WG45 as the stable mapping.
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| Preferred Name | DNA gyrase subunit A/DNA gyrase subunit B |
| Target Type | PROTEIN COMPLEX |
| Organism | Mycobacterium tuberculosis (strain ATCC 25618 / H37Rv) |
| UniProt | P9WG45 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | DNA gyrase subunit B |
| UniProt Accession | P9WG45 |
| Component Type | Protein |
| Sequence Length | 675 aa |
DNA gyrase subunit B
Review this target as DNA gyrase subunit A/DNA gyrase subunit B, mapped to UniProt P9WG45. ChEMBL maps the protein component as DNA gyrase subunit B. Sequence length is 675 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5612596 | 8.39 | IC50 | 4.1 | Preclinical |
| CHEMBL4238919 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL4250651 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL36506 | 7.82 | IC50 | 15.0 | Approved |
| CHEMBL3114205 | 7.52 | IC50 | 30.0 | Preclinical |
| CHEMBL3114216 | 7.29 | IC50 | 51.0 | Preclinical |
| CHEMBL3286436 | 7.19 | IC50 | 65.0 | Preclinical |
| CHEMBL3608760 | 6.98 | IC50 | 104.0 | Preclinical |
| CHEMBL3290337 | 6.96 | IC50 | 110.0 | Preclinical |
| CHEMBL3608758 | 6.96 | IC50 | 110.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 25 | 297 | 5.2 |
| protein complex format | 13 | 32 | 5.6 |