Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 · PROTEIN-PROTEIN INTERACTION · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt P46937. Use UniProt P46937 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P46937 as the stable identity anchor, then attach disease evidence before program review.
Transcriptional coactivator YAP1
Review this target as Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1, mapped to UniProt P46937. ChEMBL maps the protein component as Transcriptional coactivator YAP1. Sequence length is 504 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 as ChEMBL target CHEMBL3430909, mapped to UniProt P46937. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 is the right protein anchor across sources, using UniProt P46937 as the stable mapping.
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| Preferred Name | Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1 |
| Target Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
| UniProt | P46937 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Transcriptional coactivator YAP1 |
| UniProt Accession | P46937 |
| Component Type | Protein |
| Sequence Length | 504 aa |
Transcriptional coactivator YAP1
Review this target as Transcriptional coactivator YAP1/Transcriptional enhancer factor TEF-1, mapped to UniProt P46937. ChEMBL maps the protein component as Transcriptional coactivator YAP1. Sequence length is 504 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL3335461 | 7.82 | Kd | 15.0 | Preclinical |
| CHEMBL3335453 | 7.75 | Kd | 18.0 | Preclinical |
| CHEMBL3335461 | 7.6 | IC50 | 25.0 | Preclinical |
| CHEMBL3335452 | 7.41 | Kd | 39.0 | Preclinical |
| CHEMBL3335458 | 7.39 | IC50 | 41.0 | Preclinical |
| CHEMBL3335453 | 7.38 | IC50 | 42.0 | Preclinical |
| CHEMBL3335463 | 7.12 | IC50 | 75.0 | Preclinical |
| CHEMBL3335452 | 6.82 | IC50 | 150.0 | Preclinical |
| CHEMBL3335451 | 6.68 | Kd | 211.0 | Preclinical |
| CHEMBL3335456 | 6.51 | IC50 | 310.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 6 | 6 | 6.5 |
| protein format | 2 | 20 | 6.0 |