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Target Snapshot

CHEMBL3439 Target Snapshot

Glutamyl aminopeptidase · SINGLE PROTEIN · Homo sapiens

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69Compounds
8Assays
0Approved Drugs
65.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Glutamyl aminopeptidase shows late clinical disease relevance led by hypertension. 4 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q07075. Start with hypertension, then reuse UniProt Q07075 as the stable protein anchor across project notes and exports.

Review focus
Review-ready target frame

Start with hypertension, then reuse UniProt Q07075 as the stable protein anchor across project notes and exports.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14 1 linked drug
Open source guide
Disease program
hypertension

Glutamyl aminopeptidase shows late clinical disease relevance led by hypertension. 4 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.

Start review with hypertension because it currently carries late clinical support. Linked drugs include FIRIBASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Disease source · ChEMBL drug mechanism + indication proxy
Late clinical Open Targets-ready proxy 1 linked drug
Open disease block
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Glutamyl aminopeptidase as ChEMBL target CHEMBL3439, mapped to UniProt Q07075. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Glutamyl aminopeptidase
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3439
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q07075
Glutamyl aminopeptidase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Glutamyl aminopeptidase is the right protein anchor across sources, using UniProt Q07075 as the stable mapping.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need to confirm why hypertension is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.

Jump to Disease Context
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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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Preferred NameGlutamyl aminopeptidase
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtQ07075
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelGlutamyl aminopeptidase
UniProt AccessionQ07075
Component TypeProtein
Sequence Length957 aa

Glutamyl aminopeptidase

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Glutamyl aminopeptidase, mapped to UniProt Q07075. Sequence length is 957 aa.

Mapped IDQ07075
Review nameGlutamyl aminopeptidase
OrganismHomo sapiens
Disease Relevance

Disease Relevance & Evidence Level

Open Targets-ready disease context using the current target-indication evidence contract.

Late clinical Open Targets-ready proxy

Glutamyl aminopeptidase shows late clinical disease relevance led by hypertension. 4 more disease programs remain visible in the same review block.

Late clinical Phase III
hypertension
1 linked drug · 1 direct · 1 efficacy
Linked drugFIRIBASTAT
Clinical signal Phase II
essential hypertension
1 linked drug · 1 direct · 1 efficacy
Linked drugFIRIBASTAT
Clinical signal Phase II
heart failure
1 linked drug · 1 direct · 1 efficacy
Linked drugFIRIBASTAT
Clinical signal Phase II
myocardial infarction
1 linked drug · 1 direct · 1 efficacy
Linked drugFIRIBASTAT
Clinical signal Phase I
kidney failure
1 linked drug · 1 direct · 1 efficacy
Linked drugFIRIBASTAT
Source · ChEMBL drug mechanism + indication proxy
ChEMBL target record ↗
Review Cue

How to read disease relevance

Start review with hypertension because it currently carries late clinical support. Linked drugs include FIRIBASTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.

Lead diseasehypertension
Strongest levelLate clinical
Block modeOpen Targets-ready proxy
Assay Mix

Activity Type Distribution

KI65.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL146746 9.06 Ki 0.873 Preclinical
CHEMBL358903 8.49 Ki 3.2 Preclinical
CHEMBL348205 8.45 Ki 3.56 Preclinical
CHEMBL148777 8.44 Ki 3.6 Preclinical
CHEMBL151631 8.42 Ki 3.83 Preclinical
CHEMBL147285 8.37 Ki 4.3 Preclinical
CHEMBL359101 8.27 Ki 5.36 Preclinical
CHEMBL347763 8.03 Ki 9.3 Preclinical
CHEMBL356858 7.92 Ki 12.0 Preclinical
CHEMBL346397 7.89 Ki 13.0 Preclinical
Distribution

pChEMBL Value Distribution

4
5.0
11
5.5
9
6.0
13
6.5
8
7.0
8
7.5
7
8.0
0
8.5
1
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

8
Total Assays
62
Tested Compounds
1
Assay Types
Binding — 8 assays, 62 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 8 62 6.7

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine