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Target Snapshot

CHEMBL3454 Target Snapshot

Dipeptidyl peptidase 1 · SINGLE PROTEIN · Mus musculus

11Compounds
20Assays
0Approved Drugs
9.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P97821. Use UniProt P97821 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P97821 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Dipeptidyl peptidase 1 as ChEMBL target CHEMBL3454, mapped to UniProt P97821. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Dipeptidyl peptidase 1
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3454
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P97821
Dipeptidyl peptidase 1
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Dipeptidyl peptidase 1 is the right protein anchor across sources, using UniProt P97821 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelDipeptidyl peptidase 1
UniProt AccessionP97821
Component TypeProtein
Sequence Length462 aa

Dipeptidyl peptidase 1

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Dipeptidyl peptidase 1, mapped to UniProt P97821. Sequence length is 462 aa.

Mapped IDP97821
Review nameDipeptidyl peptidase 1
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

1
Phase III
Assay Mix

Activity Type Distribution

IC501.0
KI8.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL3900409 7.6 IC50 25.12 Clinical
CHEMBL543631 4.41 Ki 39000.0 Preclinical
CHEMBL552706 4.4 Ki 40000.0 Preclinical
Distribution

pChEMBL Value Distribution

0
5.0
0
5.5
0
6.0
0
6.5
0
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

20
Total Assays
9
Tested Compounds
1
Assay Types
Binding — 20 assays, 9 compounds
BAO Format Assays Compounds Avg pChEMBL
cell-based format 9 0
tissue-based format 9 0
single protein format 2 9 5.5

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine