5-hydroxytryptamine receptor 1B · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-13Protein identity stays anchored to UniProt P28564. Use UniProt P28564 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P28564 as the stable identity anchor, then attach disease evidence before program review.
5-hydroxytryptamine receptor 1B
Review this target as 5-hydroxytryptamine receptor 1B, mapped to UniProt P28564. Sequence length is 386 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats 5-hydroxytryptamine receptor 1B as ChEMBL target CHEMBL3459, mapped to UniProt P28564. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether 5-hydroxytryptamine receptor 1B is the right protein anchor across sources, using UniProt P28564 as the stable mapping.
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| Preferred Name | 5-hydroxytryptamine receptor 1B |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P28564 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | 5-hydroxytryptamine receptor 1B |
| UniProt Accession | P28564 |
| Component Type | Protein |
| Sequence Length | 386 aa |
5-hydroxytryptamine receptor 1B
Review this target as 5-hydroxytryptamine receptor 1B, mapped to UniProt P28564. Sequence length is 386 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL442 | 10.04 | Ki | 0.091 | Approved |
| CHEMBL442 | 9.7 | IC50 | 0.201 | Approved |
| CHEMBL1732 | 9.42 | Ki | 0.384 | Approved |
| CHEMBL147503 | 9.3 | IC50 | 0.5 | Preclinical |
| CHEMBL26379 | 9.1 | IC50 | 0.8 | Preclinical |
| CHEMBL1732 | 9.07 | IC50 | 0.846 | Approved |
| CHEMBL762 | 9.04 | Ki | 0.909 | Approved |
| CHEMBL146735 | 9.03 | IC50 | 0.93 | Preclinical |
| CHEMBL39 | 8.96 | Ki | 1.1 | Clinical |
| CHEMBL26378 | 8.92 | IC50 | 1.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 47 | 151 | 6.2 |
| tissue-based format | 43 | 126 | 6.4 |
| assay format | 23 | 64 | 6.5 |
| cell membrane format | 9 | 57 | 6.5 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 1 | 7.2 |