Sigma non-opioid intracellular receptor 1 · SINGLE PROTEIN · Mus musculus
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As of 2026-09-14Protein identity stays anchored to UniProt O55242. Use UniProt O55242 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O55242 as the stable identity anchor, then attach disease evidence before program review.
Sigma non-opioid intracellular receptor 1
Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt O55242. Sequence length is 223 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Sigma non-opioid intracellular receptor 1 as ChEMBL target CHEMBL3465, mapped to UniProt O55242. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Sigma non-opioid intracellular receptor 1 is the right protein anchor across sources, using UniProt O55242 as the stable mapping.
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| Preferred Name | Sigma non-opioid intracellular receptor 1 |
| Target Type | SINGLE PROTEIN |
| Organism | Mus musculus |
| UniProt | O55242 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Sigma non-opioid intracellular receptor 1 |
| UniProt Accession | O55242 |
| Component Type | Protein |
| Sequence Length | 223 aa |
Sigma non-opioid intracellular receptor 1
Review this target as Sigma non-opioid intracellular receptor 1, mapped to UniProt O55242. Sequence length is 223 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL342267 | 9.0 | Ki | 1.0 | Preclinical |
| CHEMBL592 | 8.72 | Ki | 1.9 | Approved |
| CHEMBL134684 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL136495 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL136615 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL136642 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL137768 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL335327 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL344422 | 8.7 | Ki | 2.0 | Preclinical |
| CHEMBL538532 | 8.7 | Ki | 2.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 147 | 7.7 |
| cell membrane format | 4 | 1 | 8.5 |
| cell-based format | 2 | 4 | 6.5 |