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Target Snapshot

CHEMBL347 Target Snapshot

Streptococcus pneumoniae · ORGANISM · Streptococcus pneumoniae

Back to Search Search this target Browse approvals Evidence Card
11,646Compounds
4,061Assays
8Approved Drugs
214.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-13

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-13
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Streptococcus pneumoniae as ChEMBL target CHEMBL347. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Streptococcus pneumoniae
ORGANISM · Streptococcus pneumoniae
As of 2026-09-13
ChEMBL target ID
CHEMBL347
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-13
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-13
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Streptococcus pneumoniae still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

Open the one-page evidence card when you want the rationale, activity base, and attribution together.

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameStreptococcus pneumoniae
Target TypeORGANISM
OrganismStreptococcus pneumoniae
ChEMBL ↗ NCBI Taxonomy ↗

Next Actions

SearchRun a focused querySearch the database using this target name as the starting context. ApprovalsCheck approved moleculesSee which approved drugs connect back to this target and its surrounding signal space. FeedScan papers & updatesStay in the project thread while checking recent papers and platform updates.
UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelStreptococcus pneumoniae
UniProt AccessionN/A

Streptococcus pneumoniae

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as Streptococcus pneumoniae.

Review nameStreptococcus pneumoniae
OrganismStreptococcus pneumoniae
Clinical Profile

Clinical Phase Distribution

8
Approved
1
Phase III
Assay Mix

Activity Type Distribution

IC50199.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL532 7.43 IC50 37.0 Approved
CHEMBL3989904 7.4 IC50 40.0 Clinical
CHEMBL335552 7.16 IC50 70.0 Preclinical
CHEMBL435997 7.1 IC50 80.0 Preclinical
CHEMBL1741 7.05 IC50 90.0 Approved
CHEMBL334627 7.0 IC50 100.0 Preclinical
CHEMBL262777 6.92 IC50 120.0 Approved
CHEMBL335696 6.82 IC50 150.0 Preclinical
CHEMBL529 6.77 IC50 170.0 Approved
CHEMBL4638561 6.57 IC50 270.0 Preclinical
Distribution

pChEMBL Value Distribution

32
5.0
14
5.5
19
6.0
8
6.5
7
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Approved Drugs

Approved Drugs

CLARITHROMYCIN
CHEMBL1741
Approved 1991
Properties Compare Identifier
AZITHROMYCIN
CHEMBL529
Approved 1991
Properties Compare Identifier
IMIPENEM ANHYDROUS
CHEMBL148
Approved 1985
Properties Compare Identifier
CEFTRIAXONE
CHEMBL161
Approved 1984
Properties Compare Identifier
ERYTHROMYCIN
CHEMBL532
Approved 1964
Properties Compare Identifier
VANCOMYCIN
CHEMBL262777
Approved 1964
Properties Compare Identifier
Assay Landscape

Assay Landscape

4,061
Total Assays
71
Tested Compounds
2
Assay Types
Functional — 4,032 assays, 71 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 3,944 69 5.5
assay format 88 2 5.5
ADME — 29 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 29 0 —

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine