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Target Snapshot

CHEMBL3473 Target Snapshot

C-C chemokine receptor type 3 · SINGLE PROTEIN · Homo sapiens

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1,371Compounds
175Assays
0Approved Drugs
1,412.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P51677. Use UniProt P51677 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P51677 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats C-C chemokine receptor type 3 as ChEMBL target CHEMBL3473, mapped to UniProt P51677. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
C-C chemokine receptor type 3
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3473
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P51677
C-C chemokine receptor type 3
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether C-C chemokine receptor type 3 is the right protein anchor across sources, using UniProt P51677 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

Preferred NameC-C chemokine receptor type 3
Target TypeSINGLE PROTEIN
OrganismHomo sapiens
UniProtP51677
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelC-C chemokine receptor type 3
UniProt AccessionP51677
Component TypeProtein
Sequence Length355 aa

C-C chemokine receptor type 3

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as C-C chemokine receptor type 3, mapped to UniProt P51677. Sequence length is 355 aa.

Mapped IDP51677
Review nameC-C chemokine receptor type 3
OrganismHomo sapiens
Clinical Profile

Clinical Phase Distribution

1
Phase II
1
Phase I
Assay Mix

Activity Type Distribution

IC50968.0
KI437.0
EC505.0
KD2.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL363840 11.0 IC50 0.01 Preclinical
CHEMBL257074 10.96 IC50 0.011 Preclinical
CHEMBL254930 10.89 IC50 0.013 Preclinical
CHEMBL437031 10.89 IC50 0.013 Preclinical
CHEMBL365820 10.82 IC50 0.015 Preclinical
CHEMBL2113074 10.8 IC50 0.016 Preclinical
CHEMBL257293 10.7 IC50 0.02 Preclinical
CHEMBL270582 10.7 IC50 0.02 Preclinical
CHEMBL427728 10.7 IC50 0.02 Preclinical
CHEMBL404122 10.68 IC50 0.021 Preclinical
Distribution

pChEMBL Value Distribution

76
5.0
84
5.5
139
6.0
135
6.5
191
7.0
157
7.5
179
8.0
193
8.5
92
9.0
21
9.5
pChEMBL
Assay Landscape

Assay Landscape

175
Total Assays
981
Tested Compounds
2
Assay Types
Binding — 107 assays, 981 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 65 327 7.0
cell-based format 40 619 7.6
assay format 2 35 8.0
Functional — 68 assays, 259 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 41 179 8.0
cell-based format 25 79 7.1
single protein format 2 1 7.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine