Inhibitor of nuclear factor kappa-B kinase subunit alpha · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O15111. Use UniProt O15111 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O15111 as the stable identity anchor, then attach disease evidence before program review.
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit alpha, mapped to UniProt O15111. Sequence length is 745 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Inhibitor of nuclear factor kappa-B kinase subunit alpha as ChEMBL target CHEMBL3476, mapped to UniProt O15111. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O15111 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Inhibitor of nuclear factor kappa-B kinase subunit alpha |
| UniProt Accession | O15111 |
| Component Type | Protein |
| Sequence Length | 745 aa |
Inhibitor of nuclear factor kappa-B kinase subunit alpha
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit alpha, mapped to UniProt O15111. Sequence length is 745 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL384467 | 9.3 | IC50 | 0.5 | Approved |
| CHEMBL388978 | 8.24 | Kd | 5.8 | Preclinical |
| CHEMBL5866553 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL2164410 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL2164411 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL2164412 | 8.2 | IC50 | 6.31 | Preclinical |
| CHEMBL549478 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL558491 | 8.15 | IC50 | 7.0 | Preclinical |
| CHEMBL2164417 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL551773 | 8.1 | IC50 | 8.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 300 | 350 | 6.2 |
| cell-based format | 64 | 33 | 5.9 |
| assay format | 42 | 39 | 5.4 |
| subcellular format | 13 | 0 | — |
| tissue-based format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 36 | 6.0 |