Use UniProt P16586 as the stable identity anchor, then attach disease evidence before program review.
CHEMBL3479 Target Snapshot
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' · SINGLE PROTEIN · Bos taurus
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As of 2026-09-14Protein identity stays anchored to UniProt P16586. Use UniProt P16586 as the stable identity anchor, then attach disease evidence before program review.
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
Review this target as Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', mapped to UniProt P16586. Sequence length is 855 aa.
Protein source · UniProt accession via ChEMBL component mappingCross-source identity
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This review treats Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' as ChEMBL target CHEMBL3479, mapped to UniProt P16586. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' is the right protein anchor across sources, using UniProt P16586 as the stable mapping.
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| Preferred Name | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
| Target Type | SINGLE PROTEIN |
| Organism | Bos taurus |
| UniProt | P16586 |
Next Actions
UniProt Target Context
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha' |
| UniProt Accession | P16586 |
| Component Type | Protein |
| Sequence Length | 855 aa |
Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha'
How to read this target
Review this target as Cone cGMP-specific 3',5'-cyclic phosphodiesterase subunit alpha', mapped to UniProt P16586. Sequence length is 855 aa.
Clinical Phase Distribution
Activity Type Distribution
Top Inhibitors (by pChEMBL)
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL192 | 7.48 | IC50 | 33.0 | Approved |
pChEMBL Value Distribution
Approved Drugs
Assay Landscape
Binding — 1 assays, 1 compounds
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 1 | 7.5 |