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Target Snapshot

CHEMBL3490 Target Snapshot

11-beta-hydroxysteroid dehydrogenase type 2 · SINGLE PROTEIN · Mus musculus

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362Compounds
25Assays
0Approved Drugs
324.0Activities
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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P51661. Use UniProt P51661 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P51661 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats 11-beta-hydroxysteroid dehydrogenase type 2 as ChEMBL target CHEMBL3490, mapped to UniProt P51661. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
11-beta-hydroxysteroid dehydrogenase type 2
SINGLE PROTEIN · Mus musculus
As of 2026-09-14
ChEMBL target ID
CHEMBL3490
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P51661
11-beta-hydroxysteroid dehydrogenase type 2
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether 11-beta-hydroxysteroid dehydrogenase type 2 is the right protein anchor across sources, using UniProt P51661 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
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Overview

Basic Information

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Preferred Name11-beta-hydroxysteroid dehydrogenase type 2
Target TypeSINGLE PROTEIN
OrganismMus musculus
UniProtP51661
ChEMBL ↗ UniProt ↗ NCBI Protein ↗

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein Label11-beta-hydroxysteroid dehydrogenase type 2
UniProt AccessionP51661
Component TypeProtein
Sequence Length386 aa

11-beta-hydroxysteroid dehydrogenase type 2

Source · UniProt accession via ChEMBL component mapping
UniProt Context ↗
Review Cue

How to read this target

Review this target as 11-beta-hydroxysteroid dehydrogenase type 2, mapped to UniProt P51661. Sequence length is 386 aa.

Mapped IDP51661
Review name11-beta-hydroxysteroid dehydrogenase type 2
OrganismMus musculus
Clinical Profile

Clinical Phase Distribution

2
Phase II
Assay Mix

Activity Type Distribution

IC50320.0
EC504.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL499915 7.09 EC50 82.0 Clinical
CHEMBL499915 7.09 IC50 82.0 Clinical
CHEMBL246047 6.85 IC50 140.0 Preclinical
CHEMBL1761135 6.72 IC50 190.0 Preclinical
CHEMBL245647 6.27 IC50 540.0 Preclinical
CHEMBL376695 6.11 IC50 780.0 Preclinical
CHEMBL222365 5.96 IC50 1100.0 Preclinical
CHEMBL246678 5.92 IC50 1200.0 Preclinical
CHEMBL246888 5.92 IC50 1200.0 Preclinical
CHEMBL247286 5.82 IC50 1500.0 Preclinical
Distribution

pChEMBL Value Distribution

13
5.0
12
5.5
2
6.0
3
6.5
2
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

25
Total Assays
61
Tested Compounds
2
Assay Types
Binding — 24 assays, 61 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 16 55 5.0
cell-based format 7 6 6.7
assay format 1 0 —
ADME — 1 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 1 1 5.1

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine