Mineralocorticoid receptor · SINGLE PROTEIN · Rattus norvegicus
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As of 2026-09-14Protein identity stays anchored to UniProt P22199. Use UniProt P22199 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P22199 as the stable identity anchor, then attach disease evidence before program review.
Mineralocorticoid receptor
Review this target as Mineralocorticoid receptor, mapped to UniProt P22199. Sequence length is 981 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Mineralocorticoid receptor as ChEMBL target CHEMBL3507, mapped to UniProt P22199. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Mineralocorticoid receptor is the right protein anchor across sources, using UniProt P22199 as the stable mapping.
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| Preferred Name | Mineralocorticoid receptor |
| Target Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
| UniProt | P22199 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Mineralocorticoid receptor |
| UniProt Accession | P22199 |
| Component Type | Protein |
| Sequence Length | 981 aa |
Mineralocorticoid receptor
Review this target as Mineralocorticoid receptor, mapped to UniProt P22199. Sequence length is 981 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2181928 | 8.49 | IC50 | 3.2 | Preclinical |
| CHEMBL4532472 | 8.1 | IC50 | 7.943 | Preclinical |
| CHEMBL4540313 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL2181930 | 7.68 | IC50 | 21.0 | Preclinical |
| CHEMBL2181931 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL4087750 | 7.66 | IC50 | 22.0 | Preclinical |
| CHEMBL2181929 | 7.51 | Ki | 30.8 | Clinical |
| CHEMBL4085281 | 7.51 | IC50 | 31.0 | Preclinical |
| CHEMBL1095097 | 7.4 | IC50 | 39.81 | Approved |
| CHEMBL273453 | 7.37 | IC50 | 43.0 | Clinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| tissue-based format | 31 | 0 | — |
| organism-based format | 24 | 0 | — |
| assay format | 10 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 33 | 28 | 6.1 |
| assay format | 5 | 7 | 7.3 |
| cell-based format | 4 | 17 | 6.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 1 | 0 | — |