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Target Snapshot

CHEMBL3511 Target Snapshot

Ornithine decarboxylase · SINGLE PROTEIN · Rattus norvegicus

118Compounds
48Assays
1Approved Drugs
66.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt P09057. Use UniProt P09057 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt P09057 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Ornithine decarboxylase as ChEMBL target CHEMBL3511, mapped to UniProt P09057. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Ornithine decarboxylase
SINGLE PROTEIN · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL3511
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
P09057
Ornithine decarboxylase
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Ornithine decarboxylase is the right protein anchor across sources, using UniProt P09057 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelOrnithine decarboxylase
UniProt AccessionP09057
Component TypeProtein
Sequence Length461 aa

Ornithine decarboxylase

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Ornithine decarboxylase, mapped to UniProt P09057. Sequence length is 461 aa.

Mapped IDP09057
Review nameOrnithine decarboxylase
OrganismRattus norvegicus
Clinical Profile

Clinical Phase Distribution

1
Approved
Assay Mix

Activity Type Distribution

IC5019.0
KI47.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL27061 7.85 IC50 14.0 Preclinical
CHEMBL26435 7.48 IC50 33.0 Preclinical
CHEMBL1209776 7.46 IC50 35.0 Preclinical
CHEMBL281021 7.46 IC50 35.0 Preclinical
CHEMBL26857 7.41 IC50 39.0 Preclinical
CHEMBL3216925 7.41 IC50 39.0 Preclinical
CHEMBL284573 7.31 IC50 49.0 Preclinical
CHEMBL15650 7.03 IC50 93.0 Preclinical
CHEMBL282411 5.96 IC50 1100.0 Preclinical
CHEMBL26797 5.72 IC50 1900.0 Preclinical
Distribution

pChEMBL Value Distribution

5
5.0
6
5.5
0
6.0
0
6.5
7
7.0
1
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

48
Total Assays
48
Tested Compounds
2
Assay Types
Functional — 24 assays, 4 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 17 0
assay format 5 0
tissue-based format 2 4
Binding — 24 assays, 48 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 15 39 5.5
single protein format 7 4 5.4
cell-based format 2 5 4.4

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine