Histone deacetylase 4 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt P56524. Use UniProt P56524 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P56524 as the stable identity anchor, then attach disease evidence before program review.
Histone deacetylase 4
Review this target as Histone deacetylase 4, mapped to UniProt P56524. Sequence length is 1084 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Histone deacetylase 4 as ChEMBL target CHEMBL3524, mapped to UniProt P56524. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Histone deacetylase 4 is the right protein anchor across sources, using UniProt P56524 as the stable mapping.
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| Preferred Name | Histone deacetylase 4 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P56524 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Histone deacetylase 4 |
| UniProt Accession | P56524 |
| Component Type | Protein |
| Sequence Length | 1084 aa |
Histone deacetylase 4
Review this target as Histone deacetylase 4, mapped to UniProt P56524. Sequence length is 1084 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2408237 | 10.1 | Ki | 0.08 | Preclinical |
| CHEMBL3692689 | 10.1 | IC50 | 0.08 | Preclinical |
| CHEMBL2105763 | 9.52 | Ki | 0.3 | Clinical |
| CHEMBL144205 | 9.52 | IC50 | 0.3 | Preclinical |
| CHEMBL2408238 | 9.27 | Ki | 0.54 | Preclinical |
| CHEMBL483254 | 9.22 | Ki | 0.6 | Approved |
| CHEMBL2105763 | 9.22 | IC50 | 0.6 | Clinical |
| CHEMBL3692678 | 9.12 | IC50 | 0.75 | Preclinical |
| CHEMBL3692671 | 9.01 | IC50 | 0.97 | Preclinical |
| CHEMBL430060 | 9.0 | IC50 | 1.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 355 | 729 | 6.4 |
| cell-based format | 119 | 464 | 6.5 |
| assay format | 52 | 111 | 6.1 |
| organism-based format | 1 | 0 | — |
| subcellular format | 1 | 0 | — |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 6 | 3 | 5.1 |
| cell-based format | 3 | 5 | 5.7 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 2 | 1 | 4.8 |
| cell-based format | 1 | 1 | 5.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 2 | 11 | 5.6 |