Inhibitor of nuclear factor kappa-B kinase subunit epsilon · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Protein identity stays anchored to UniProt Q14164. Use UniProt Q14164 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt Q14164 as the stable identity anchor, then attach disease evidence before program review.
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit epsilon, mapped to UniProt Q14164. Sequence length is 716 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Inhibitor of nuclear factor kappa-B kinase subunit epsilon as ChEMBL target CHEMBL3529, mapped to UniProt Q14164. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | Q14164 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Inhibitor of nuclear factor kappa-B kinase subunit epsilon |
| UniProt Accession | Q14164 |
| Component Type | Protein |
| Sequence Length | 716 aa |
Inhibitor of nuclear factor kappa-B kinase subunit epsilon
Review this target as Inhibitor of nuclear factor kappa-B kinase subunit epsilon, mapped to UniProt Q14164. Sequence length is 716 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL388978 | 9.7 | IC50 | 0.199 | Preclinical |
| CHEMBL3682430 | 9.0 | IC50 | 1.0 | Preclinical |
| CHEMBL3687186 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4537673 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL4566796 | 8.7 | IC50 | 2.0 | Preclinical |
| CHEMBL2011940 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3682423 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL3682431 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4436188 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4454902 | 8.4 | IC50 | 4.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 260 | 315 | 6.5 |
| assay format | 32 | 36 | 7.2 |
| cell-based format | 31 | 36 | 5.6 |
| subcellular format | 23 | 34 | 6.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 97 | 5.8 |
| cell-based format | 1 | 1 | 7.1 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 0 | — |