Dual specificity mitogen-activated protein kinase kinase 7 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-14Protein identity stays anchored to UniProt O14733. Use UniProt O14733 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt O14733 as the stable identity anchor, then attach disease evidence before program review.
Dual specificity mitogen-activated protein kinase kinase 7
Review this target as Dual specificity mitogen-activated protein kinase kinase 7, mapped to UniProt O14733. Sequence length is 419 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dual specificity mitogen-activated protein kinase kinase 7 as ChEMBL target CHEMBL3530, mapped to UniProt O14733. Disease framing currently uses the Open Targets-ready proxy contract.
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| Preferred Name | Dual specificity mitogen-activated protein kinase kinase 7 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | O14733 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dual specificity mitogen-activated protein kinase kinase 7 |
| UniProt Accession | O14733 |
| Component Type | Protein |
| Sequence Length | 419 aa |
Dual specificity mitogen-activated protein kinase kinase 7
Review this target as Dual specificity mitogen-activated protein kinase kinase 7, mapped to UniProt O14733. Sequence length is 419 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL4764965 | 9.22 | IC50 | 0.6 | Preclinical |
| CHEMBL3329977 | 8.72 | IC50 | 1.9 | Preclinical |
| CHEMBL5174214 | 8.52 | IC50 | 3.0 | Preclinical |
| CHEMBL5195838 | 8.4 | IC50 | 4.0 | Preclinical |
| CHEMBL4749823 | 8.3 | IC50 | 5.0 | Preclinical |
| CHEMBL3901151 | 8.22 | IC50 | 6.0 | Preclinical |
| CHEMBL5284723 | 8.0 | IC50 | 10.0 | Preclinical |
| CHEMBL4787266 | 7.85 | IC50 | 14.0 | Preclinical |
| CHEMBL574738 | 7.57 | Kd | 27.0 | Preclinical |
| CHEMBL388978 | 7.52 | Kd | 30.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 142 | 45 | 6.5 |
| assay format | 32 | 27 | 6.4 |
| cell-based format | 25 | 25 | 5.7 |
| subcellular format | 10 | 0 | — |