Non-receptor tyrosine-protein kinase TYK2 · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Non-receptor tyrosine-protein kinase TYK2 shows approved-linked disease relevance led by alopecia areata. 5 more disease programs remain visible in the same review block. 3 linked drugs keep the current disease frame grounded. Protein identity stays anchored to UniProt P29597. Start with alopecia areata, then reuse UniProt P29597 as the stable protein anchor across project notes and exports.
Start with alopecia areata, then reuse UniProt P29597 as the stable protein anchor across project notes and exports.
Non-receptor tyrosine-protein kinase TYK2 shows approved-linked disease relevance led by alopecia areata. 5 more disease programs remain visible in the same review block. 3 linked drugs remain visible in the same block.
Start review with alopecia areata because it currently carries approved-linked support. Linked drugs include BREPOCITINIB, DEUCRAVACITINIB, DEURUXOLITINIB PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyNon-receptor tyrosine-protein kinase TYK2
Review this target as Non-receptor tyrosine-protein kinase TYK2, mapped to UniProt P29597. Sequence length is 1187 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Non-receptor tyrosine-protein kinase TYK2 as ChEMBL target CHEMBL3553, mapped to UniProt P29597. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
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Start here when your first question is whether Non-receptor tyrosine-protein kinase TYK2 is the right protein anchor across sources, using UniProt P29597 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why alopecia areata is currently framed as approved-linked support. It currently carries 3 linked drugs in the same disease frame.
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Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Non-receptor tyrosine-protein kinase TYK2 |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P29597 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Non-receptor tyrosine-protein kinase TYK2 |
| UniProt Accession | P29597 |
| Component Type | Protein |
| Sequence Length | 1187 aa |
Non-receptor tyrosine-protein kinase TYK2
Review this target as Non-receptor tyrosine-protein kinase TYK2, mapped to UniProt P29597. Sequence length is 1187 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Non-receptor tyrosine-protein kinase TYK2 shows approved-linked disease relevance led by alopecia areata. 5 more disease programs remain visible in the same review block.
Start review with alopecia areata because it currently carries approved-linked support. Linked drugs include BREPOCITINIB, DEUCRAVACITINIB, DEURUXOLITINIB PHOSPHATE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL5427107 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL4460368 | 10.82 | Ki | 0.015 | Preclinical |
| CHEMBL5427277 | 10.8 | IC50 | 0.016 | Preclinical |
| CHEMBL4442827 | 10.74 | Ki | 0.018 | Preclinical |
| CHEMBL5422022 | 10.74 | IC50 | 0.018 | Preclinical |
| CHEMBL5424497 | 10.72 | Kd | 0.019 | Preclinical |
| CHEMBL5433700 | 10.72 | Kd | 0.019 | Preclinical |
| CHEMBL4435170 | 10.7 | Ki | 0.02 | Approved |
| CHEMBL4789639 | 10.7 | Ki | 0.02 | Preclinical |
| CHEMBL5398548 | 10.64 | Kd | 0.023 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 628 | 5,170 | 7.5 |
| cell-based format | 107 | 1,439 | 8.8 |
| assay format | 86 | 190 | 6.9 |
| subcellular format | 19 | 11 | 6.5 |
| tissue-based format | 9 | 122 | 7.0 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 25 | 2 | 6.8 |
| tissue-based format | 13 | 2 | 6.9 |
| assay format | 1 | 86 | 6.6 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| assay format | 1 | 8 | 5.8 |