Steryl-sulfatase · SINGLE PROTEIN · Homo sapiens
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As of 2026-09-13Steryl-sulfatase shows clinical signal disease relevance led by breast cancer. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt P08842. Start with breast cancer, then reuse UniProt P08842 as the stable protein anchor across project notes and exports.
Start with breast cancer, then reuse UniProt P08842 as the stable protein anchor across project notes and exports.
Steryl-sulfatase shows clinical signal disease relevance led by breast cancer. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with breast cancer because it currently carries clinical signal support. Linked drugs include IROSUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxySteryl-sulfatase
Review this target as Steryl-sulfatase, mapped to UniProt P08842. Sequence length is 583 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Steryl-sulfatase as ChEMBL target CHEMBL3559, mapped to UniProt P08842. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether Steryl-sulfatase is the right protein anchor across sources, using UniProt P08842 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why breast cancer is currently framed as clinical signal support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | Steryl-sulfatase |
| Target Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
| UniProt | P08842 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Steryl-sulfatase |
| UniProt Accession | P08842 |
| Component Type | Protein |
| Sequence Length | 583 aa |
Steryl-sulfatase
Review this target as Steryl-sulfatase, mapped to UniProt P08842. Sequence length is 583 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
Steryl-sulfatase shows clinical signal disease relevance led by breast cancer. 3 more disease programs remain visible in the same review block.
Start review with breast cancer because it currently carries clinical signal support. Linked drugs include IROSUSTAT. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2011408 | 11.0 | IC50 | 0.01 | Preclinical |
| CHEMBL3805209 | 10.62 | IC50 | 0.024 | Preclinical |
| CHEMBL3622029 | 10.46 | IC50 | 0.035 | Preclinical |
| CHEMBL3806018 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL4643348 | 10.4 | IC50 | 0.04 | Preclinical |
| CHEMBL137392 | 10.33 | IC50 | 0.047 | Preclinical |
| CHEMBL122708 | 10.19 | IC50 | 0.065 | Preclinical |
| CHEMBL5202760 | 10.19 | IC50 | 0.065 | Preclinical |
| CHEMBL137692 | 10.05 | IC50 | 0.089 | Preclinical |
| CHEMBL2011422 | 10.0 | IC50 | 0.1 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 138 | 211 | 7.1 |
| single protein format | 129 | 229 | 6.4 |
| assay format | 31 | 128 | 6.5 |
| microsome format | 28 | 47 | 7.3 |
| subcellular format | 2 | 4 | 6.6 |
| tissue-based format | 2 | 1 | 7.4 |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| cell-based format | 1 | 6 | 6.6 |