GP41 · SINGLE PROTEIN · Human immunodeficiency virus 1
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As of 2026-09-14GP41 shows late clinical disease relevance led by AIDS. 3 more disease programs remain visible in the same review block. 1 linked drug keeps the current disease frame grounded. Protein identity stays anchored to UniProt Q76270. Start with AIDS, then reuse UniProt Q76270 as the stable protein anchor across project notes and exports.
Start with AIDS, then reuse UniProt Q76270 as the stable protein anchor across project notes and exports.
GP41 shows late clinical disease relevance led by AIDS. 3 more disease programs remain visible in the same review block. 1 linked drug remains visible in the same block.
Start review with AIDS because it currently carries late clinical support. Linked drugs include ALBUVIRTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
Disease source · ChEMBL drug mechanism + indication proxyEnv polyprotein
Review this target as GP41, mapped to UniProt Q76270. ChEMBL maps the protein component as Env polyprotein. Sequence length is 124 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats GP41 as ChEMBL target CHEMBL3559676, mapped to UniProt Q76270. Disease framing currently uses the Open Targets-ready proxy contract.
Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.
Choose the first block or source based on the question you are trying to answer.
Start here when your first question is whether GP41 is the right protein anchor across sources, using UniProt Q76270 as the stable mapping.
Jump to Protein ContextUse this block first when you need to confirm why AIDS is currently framed as late clinical support. It currently carries 1 linked drug in the same disease frame.
Jump to Disease ContextOpen the one-page evidence card when you want the rationale, activity base, and attribution together.
Open Review-ready CardVerify identity, organism, and the fastest next research jumps from the same page.
| Preferred Name | GP41 |
| Target Type | SINGLE PROTEIN |
| Organism | Human immunodeficiency virus 1 |
| UniProt | Q76270 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Env polyprotein |
| UniProt Accession | Q76270 |
| Component Type | Protein |
| Sequence Length | 124 aa |
Env polyprotein
Review this target as GP41, mapped to UniProt Q76270. ChEMBL maps the protein component as Env polyprotein. Sequence length is 124 aa.
Open Targets-ready disease context using the current target-indication evidence contract.
GP41 shows late clinical disease relevance led by AIDS. 3 more disease programs remain visible in the same review block.
Start review with AIDS because it currently carries late clinical support. Linked drugs include ALBUVIRTIDE. This disease block keeps the Open Targets-ready contract explicit while current evidence comes from ChEMBL mechanism and indication mappings.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL2380932 | 8.89 | EC50 | 1.3 | Preclinical |
| CHEMBL3341857 | 8.48 | EC50 | 3.31 | Preclinical |
| CHEMBL3341856 | 8.47 | EC50 | 3.35 | Preclinical |
| CHEMBL3341854 | 8.4 | EC50 | 3.94 | Preclinical |
| CHEMBL3341855 | 8.1 | EC50 | 7.94 | Preclinical |
| CHEMBL525076 | 8.0 | EC50 | 10.1 | Approved |
| CHEMBL3341847 | 7.82 | EC50 | 15.1 | Preclinical |
| CHEMBL3341852 | 7.71 | EC50 | 19.6 | Preclinical |
| CHEMBL3341849 | 7.54 | EC50 | 28.6 | Preclinical |
| CHEMBL3341853 | 7.36 | EC50 | 44.2 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 5 | 11 | 5.6 |
| cell-based format | 4 | 19 | 7.3 |