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Target Snapshot

CHEMBL3562175 Target Snapshot

Protein arginine N-methyltransferase 7 · SINGLE PROTEIN · Homo sapiens

120Compounds
84Assays
0Approved Drugs
67.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Protein identity stays anchored to UniProt Q9NVM4. Use UniProt Q9NVM4 as the stable identity anchor, then attach disease evidence before program review.

Review focus
Protein anchor ready

Use UniProt Q9NVM4 as the stable identity anchor, then attach disease evidence before program review.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Protein arginine N-methyltransferase 7 as ChEMBL target CHEMBL3562175, mapped to UniProt Q9NVM4. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Protein arginine N-methyltransferase 7
SINGLE PROTEIN · Homo sapiens
As of 2026-09-14
ChEMBL target ID
CHEMBL3562175
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
UniProt accession
Q9NVM4
Protein arginine N-methyltransferase 7
UniProt accession via ChEMBL component mapping As of 2026-09-14
www.uniprot.org
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

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UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Protein arginine N-methyltransferase 7 is the right protein anchor across sources, using UniProt Q9NVM4 as the stable mapping.

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Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

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UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelProtein arginine N-methyltransferase 7
UniProt AccessionQ9NVM4
Component TypeProtein
Sequence Length692 aa

Protein arginine N-methyltransferase 7

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Protein arginine N-methyltransferase 7, mapped to UniProt Q9NVM4. Sequence length is 692 aa.

Mapped IDQ9NVM4
Review nameProtein arginine N-methyltransferase 7
OrganismHomo sapiens
Assay Mix

Activity Type Distribution

IC5066.0
KD1.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5303356 7.11 IC50 77.0 Preclinical
CHEMBL418052 6.96 IC50 110.0 Preclinical
CHEMBL5206272 6.66 IC50 220.0 Preclinical
CHEMBL5202088 6.65 IC50 226.0 Preclinical
CHEMBL5562317 6.53 IC50 294.0 Preclinical
CHEMBL5199380 6.5 IC50 320.0 Preclinical
CHEMBL5180108 6.39 IC50 410.0 Preclinical
CHEMBL5408585 6.27 IC50 540.0 Preclinical
CHEMBL5170047 6.26 IC50 550.0 Preclinical
CHEMBL5613785 6.26 IC50 555.0 Preclinical
Distribution

pChEMBL Value Distribution

6
5.0
6
5.5
6
6.0
5
6.5
1
7.0
0
7.5
0
8.0
0
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

84
Total Assays
32
Tested Compounds
2
Assay Types
Binding — 82 assays, 32 compounds
BAO Format Assays Compounds Avg pChEMBL
single protein format 61 24 5.7
cell-based format 13 3 5.5
assay format 8 5 4.6
Functional — 2 assays, 1 compounds
BAO Format Assays Compounds Avg pChEMBL
assay format 1 1 5.2
cell-based format 1 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine