Dihydrofolate reductase · SINGLE PROTEIN · Neisseria gonorrhoeae
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Structured disease, protein, and project context should read before the lower-level identity rail.
As of 2026-09-13Protein identity stays anchored to UniProt P04174. Use UniProt P04174 as the stable identity anchor, then attach disease evidence before program review.
Use UniProt P04174 as the stable identity anchor, then attach disease evidence before program review.
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P04174. Sequence length is 162 aa.
Protein source · UniProt accession via ChEMBL component mappingKeep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.
This review treats Dihydrofolate reductase as ChEMBL target CHEMBL3565, mapped to UniProt P04174. Disease framing currently uses the Open Targets-ready proxy contract.
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Start here when your first question is whether Dihydrofolate reductase is the right protein anchor across sources, using UniProt P04174 as the stable mapping.
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| Preferred Name | Dihydrofolate reductase |
| Target Type | SINGLE PROTEIN |
| Organism | Neisseria gonorrhoeae |
| UniProt | P04174 |
Reviewable protein naming and mapping context for this target snapshot.
| Protein Label | Dihydrofolate reductase |
| UniProt Accession | P04174 |
| Component Type | Protein |
| Sequence Length | 162 aa |
Dihydrofolate reductase
Review this target as Dihydrofolate reductase, mapped to UniProt P04174. Sequence length is 162 aa.
| ChEMBL ID | pChEMBL | Type | Value (nM) | Phase |
|---|---|---|---|---|
| CHEMBL23746 | 7.7 | IC50 | 20.0 | Preclinical |
| CHEMBL120366 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL118480 | 7.55 | IC50 | 28.0 | Preclinical |
| CHEMBL440946 | 7.54 | IC50 | 29.0 | Preclinical |
| CHEMBL334021 | 7.37 | IC50 | 43.0 | Preclinical |
| CHEMBL279455 | 7.36 | IC50 | 44.0 | Preclinical |
| CHEMBL432987 | 7.35 | IC50 | 45.0 | Preclinical |
| CHEMBL116993 | 7.32 | IC50 | 48.0 | Preclinical |
| CHEMBL25888 | 7.31 | IC50 | 49.0 | Preclinical |
| CHEMBL24374 | 7.24 | IC50 | 58.0 | Preclinical |
| BAO Format | Assays | Compounds | Avg pChEMBL |
|---|---|---|---|
| single protein format | 3 | 56 | 6.6 |